PrepareDataSet.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Convert input data to desired format "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "import pickle\n",
    "import pandas as pd\n",
    "import numpy as np\n",
    "from collections import Counter"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "regiondata_url = \"./gmql_data/Datasets/gs_breast_finale.pickle\"\n",
    "regiondata = pickle.load(open(regiondata_url, \"rb\"))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style>\n",
       "    .dataframe thead tr:only-child th {\n",
       "        text-align: right;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: left;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th colspan=\"21\" halign=\"left\">normalized_count</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th></th>\n",
       "      <th>gene_symbol</th>\n",
       "      <th>A1BG</th>\n",
       "      <th>A1BG-AS1</th>\n",
       "      <th>A1CF</th>\n",
       "      <th>A2M</th>\n",
       "      <th>A2M-AS1</th>\n",
       "      <th>A2ML1</th>\n",
       "      <th>A4GALT</th>\n",
       "      <th>A4GNT</th>\n",
       "      <th>AAAS</th>\n",
       "      <th>AACS</th>\n",
       "      <th>...</th>\n",
       "      <th>ZWILCH</th>\n",
       "      <th>ZWINT</th>\n",
       "      <th>ZXDA</th>\n",
       "      <th>ZXDB</th>\n",
       "      <th>ZXDC</th>\n",
       "      <th>ZYG11A</th>\n",
       "      <th>ZYG11B</th>\n",
       "      <th>ZYX</th>\n",
       "      <th>ZZEF1</th>\n",
       "      <th>ZZZ3</th>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>manually_curated__tissue_status</th>\n",
       "      <th>sample</th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
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       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "      <th></th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
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       "      <td>842.5974</td>\n",
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       "    <tr>\n",
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       "      <td>0.4078</td>\n",
       "      <td>14028.9356</td>\n",
       "      <td>15.5179</td>\n",
       "      <td>3.6705</td>\n",
       "      <td>183.9315</td>\n",
       "      <td>1.6313</td>\n",
       "      <td>676.9984</td>\n",
       "      <td>855.6281</td>\n",
       "      <td>...</td>\n",
       "      <td>569.2659</td>\n",
       "      <td>679.0375</td>\n",
       "      <td>147.6346</td>\n",
       "      <td>883.3605</td>\n",
       "      <td>1214.9266</td>\n",
       "      <td>74.6330</td>\n",
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       "      <td>716.9657</td>\n",
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       "      <td>100.7430</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>17754.2889</td>\n",
       "      <td>23.3321</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>807.9038</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>668.4097</td>\n",
       "      <td>919.9974</td>\n",
       "      <td>...</td>\n",
       "      <td>188.4209</td>\n",
       "      <td>567.5255</td>\n",
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       "      <td>520.6122</td>\n",
       "      <td>43.5919</td>\n",
       "      <td>473.2839</td>\n",
       "      <td>4341.3414</td>\n",
       "      <td>807.9038</td>\n",
       "      <td>435.0890</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00003</th>\n",
       "      <td>127.1454</td>\n",
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       "      <td>0.0000</td>\n",
       "      <td>9604.5625</td>\n",
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       "      <td>209.3284</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>919.3896</td>\n",
       "      <td>781.1018</td>\n",
       "      <td>...</td>\n",
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       "      <td>43.7969</td>\n",
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       "      <td>442.7968</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00004</th>\n",
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       "      <td>0.0000</td>\n",
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       "      <td>274.1869</td>\n",
       "      <td>4.5286</td>\n",
       "      <td>669.4113</td>\n",
       "      <td>1374.6398</td>\n",
       "      <td>...</td>\n",
       "      <td>1098.3573</td>\n",
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       "      <td>104.1581</td>\n",
       "      <td>792.9189</td>\n",
       "      <td>1813.0918</td>\n",
       "      <td>63.8123</td>\n",
       "      <td>1041.1692</td>\n",
       "      <td>4456.1548</td>\n",
       "      <td>1162.6184</td>\n",
       "      <td>901.1939</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00005</th>\n",
       "      <td>341.4830</td>\n",
       "      <td>155.5912</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>2512.5972</td>\n",
       "      <td>13.2545</td>\n",
       "      <td>0.8016</td>\n",
       "      <td>521.0421</td>\n",
       "      <td>0.4008</td>\n",
       "      <td>1204.8096</td>\n",
       "      <td>1553.1062</td>\n",
       "      <td>...</td>\n",
       "      <td>339.2024</td>\n",
       "      <td>1364.7295</td>\n",
       "      <td>18.8377</td>\n",
       "      <td>206.4128</td>\n",
       "      <td>772.3447</td>\n",
       "      <td>133.8677</td>\n",
       "      <td>554.7094</td>\n",
       "      <td>2131.8637</td>\n",
       "      <td>347.8958</td>\n",
       "      <td>412.8257</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00006</th>\n",
       "      <td>180.3284</td>\n",
       "      <td>109.5081</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>28739.2847</td>\n",
       "      <td>55.5089</td>\n",
       "      <td>3515.2196</td>\n",
       "      <td>2097.6779</td>\n",
       "      <td>0.9466</td>\n",
       "      <td>566.0701</td>\n",
       "      <td>1144.9194</td>\n",
       "      <td>...</td>\n",
       "      <td>560.8543</td>\n",
       "      <td>704.2745</td>\n",
       "      <td>40.7040</td>\n",
       "      <td>250.3772</td>\n",
       "      <td>557.0774</td>\n",
       "      <td>61.0561</td>\n",
       "      <td>533.4122</td>\n",
       "      <td>6719.9527</td>\n",
       "      <td>627.1262</td>\n",
       "      <td>587.3687</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00007</th>\n",
       "      <td>101.3246</td>\n",
       "      <td>120.9196</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>8586.3106</td>\n",
       "      <td>24.0443</td>\n",
       "      <td>0.5210</td>\n",
       "      <td>252.4259</td>\n",
       "      <td>1.0420</td>\n",
       "      <td>449.1045</td>\n",
       "      <td>767.4373</td>\n",
       "      <td>...</td>\n",
       "      <td>554.5112</td>\n",
       "      <td>1946.7275</td>\n",
       "      <td>63.5624</td>\n",
       "      <td>587.1703</td>\n",
       "      <td>1303.5493</td>\n",
       "      <td>201.6281</td>\n",
       "      <td>1058.1570</td>\n",
       "      <td>2228.3295</td>\n",
       "      <td>1602.3445</td>\n",
       "      <td>1198.8277</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00008</th>\n",
       "      <td>117.7966</td>\n",
       "      <td>73.5508</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>9871.0847</td>\n",
       "      <td>11.9661</td>\n",
       "      <td>5.0847</td>\n",
       "      <td>238.9831</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>635.5932</td>\n",
       "      <td>1027.9661</td>\n",
       "      <td>...</td>\n",
       "      <td>464.0932</td>\n",
       "      <td>1505.9322</td>\n",
       "      <td>53.3898</td>\n",
       "      <td>526.2712</td>\n",
       "      <td>752.5424</td>\n",
       "      <td>56.7797</td>\n",
       "      <td>596.6102</td>\n",
       "      <td>4315.2542</td>\n",
       "      <td>394.0678</td>\n",
       "      <td>465.2542</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00009</th>\n",
       "      <td>192.7825</td>\n",
       "      <td>251.1441</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>9226.3842</td>\n",
       "      <td>15.1412</td>\n",
       "      <td>0.4708</td>\n",
       "      <td>291.4313</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>686.4407</td>\n",
       "      <td>1049.9058</td>\n",
       "      <td>...</td>\n",
       "      <td>612.0480</td>\n",
       "      <td>599.8117</td>\n",
       "      <td>92.7495</td>\n",
       "      <td>1251.4124</td>\n",
       "      <td>1072.9755</td>\n",
       "      <td>174.6704</td>\n",
       "      <td>911.0169</td>\n",
       "      <td>6243.4087</td>\n",
       "      <td>1568.7382</td>\n",
       "      <td>1058.8512</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00010</th>\n",
       "      <td>49.1992</td>\n",
       "      <td>75.0039</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>31626.9490</td>\n",
       "      <td>28.4176</td>\n",
       "      <td>3.1535</td>\n",
       "      <td>337.4254</td>\n",
       "      <td>0.9010</td>\n",
       "      <td>711.7919</td>\n",
       "      <td>2184.0297</td>\n",
       "      <td>...</td>\n",
       "      <td>474.7652</td>\n",
       "      <td>321.2073</td>\n",
       "      <td>95.9568</td>\n",
       "      <td>519.4279</td>\n",
       "      <td>1415.9252</td>\n",
       "      <td>19.3716</td>\n",
       "      <td>1364.5681</td>\n",
       "      <td>6186.7327</td>\n",
       "      <td>1931.2986</td>\n",
       "      <td>1436.1978</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00011</th>\n",
       "      <td>222.6672</td>\n",
       "      <td>175.3532</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>10548.8553</td>\n",
       "      <td>36.7133</td>\n",
       "      <td>1.8889</td>\n",
       "      <td>202.8712</td>\n",
       "      <td>2.6445</td>\n",
       "      <td>1004.9112</td>\n",
       "      <td>576.1239</td>\n",
       "      <td>...</td>\n",
       "      <td>434.2048</td>\n",
       "      <td>728.7495</td>\n",
       "      <td>68.0015</td>\n",
       "      <td>524.3672</td>\n",
       "      <td>1290.8954</td>\n",
       "      <td>61.9569</td>\n",
       "      <td>624.4805</td>\n",
       "      <td>3007.9335</td>\n",
       "      <td>1358.5191</td>\n",
       "      <td>994.7110</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00012</th>\n",
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       "      <td>269.9923</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>28120.3800</td>\n",
       "      <td>36.4290</td>\n",
       "      <td>2312.7621</td>\n",
       "      <td>1216.8108</td>\n",
       "      <td>1.3695</td>\n",
       "      <td>276.2989</td>\n",
       "      <td>636.4804</td>\n",
       "      <td>...</td>\n",
       "      <td>684.8686</td>\n",
       "      <td>1066.5069</td>\n",
       "      <td>76.0079</td>\n",
       "      <td>452.6235</td>\n",
       "      <td>805.2726</td>\n",
       "      <td>17.4613</td>\n",
       "      <td>878.5415</td>\n",
       "      <td>7295.3865</td>\n",
       "      <td>1105.8803</td>\n",
       "      <td>1054.8660</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00013</th>\n",
       "      <td>100.5562</td>\n",
       "      <td>130.1150</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>8568.4645</td>\n",
       "      <td>18.1390</td>\n",
       "      <td>0.8364</td>\n",
       "      <td>97.0238</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>502.6835</td>\n",
       "      <td>505.1927</td>\n",
       "      <td>...</td>\n",
       "      <td>315.4778</td>\n",
       "      <td>347.6685</td>\n",
       "      <td>83.3624</td>\n",
       "      <td>625.6360</td>\n",
       "      <td>1054.7153</td>\n",
       "      <td>107.0607</td>\n",
       "      <td>1217.2580</td>\n",
       "      <td>2124.7648</td>\n",
       "      <td>1948.8395</td>\n",
       "      <td>1556.8412</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00014</th>\n",
       "      <td>616.6585</td>\n",
       "      <td>180.1730</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>7832.7832</td>\n",
       "      <td>16.7374</td>\n",
       "      <td>0.5055</td>\n",
       "      <td>179.4552</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>684.9627</td>\n",
       "      <td>1423.5091</td>\n",
       "      <td>...</td>\n",
       "      <td>195.5303</td>\n",
       "      <td>414.5162</td>\n",
       "      <td>19.7148</td>\n",
       "      <td>369.5260</td>\n",
       "      <td>926.5953</td>\n",
       "      <td>48.5287</td>\n",
       "      <td>339.7010</td>\n",
       "      <td>5440.2718</td>\n",
       "      <td>509.5516</td>\n",
       "      <td>255.7868</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>normal</th>\n",
       "      <th>files\\S_00015</th>\n",
       "      <td>80.8742</td>\n",
       "      <td>128.5481</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>25382.8067</td>\n",
       "      <td>68.6247</td>\n",
       "      <td>48.0573</td>\n",
       "      <td>512.7812</td>\n",
       "      <td>1.0225</td>\n",
       "      <td>535.7873</td>\n",
       "      <td>860.4294</td>\n",
       "      <td>...</td>\n",
       "      <td>278.1186</td>\n",
       "      <td>153.8855</td>\n",
       "      <td>63.3947</td>\n",
       "      <td>494.3763</td>\n",
       "      <td>1085.3783</td>\n",
       "      <td>20.4499</td>\n",
       "      <td>1116.5644</td>\n",
       "      <td>8266.8712</td>\n",
       "      <td>1337.9346</td>\n",
       "      <td>1019.4274</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th rowspan=\"5\" valign=\"top\">tumoral</th>\n",
       "      <th>files\\S_00016</th>\n",
       "      <td>142.8677</td>\n",
       "      <td>88.0352</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>8592.7825</td>\n",
       "      <td>26.1840</td>\n",
       "      <td>27.2572</td>\n",
       "      <td>350.9370</td>\n",
       "      <td>0.5679</td>\n",
       "      <td>563.3163</td>\n",
       "      <td>585.4628</td>\n",
       "      <td>...</td>\n",
       "      <td>423.0551</td>\n",
       "      <td>609.8807</td>\n",
       "      <td>57.3538</td>\n",
       "      <td>534.3555</td>\n",
       "      <td>1275.4117</td>\n",
       "      <td>44.8609</td>\n",
       "      <td>646.2237</td>\n",
       "      <td>3204.9972</td>\n",
       "      <td>956.2748</td>\n",
       "      <td>593.4128</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00017</th>\n",
       "      <td>111.3007</td>\n",
       "      <td>126.4392</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>29446.7761</td>\n",
       "      <td>39.4517</td>\n",
       "      <td>27.8134</td>\n",
       "      <td>263.3247</td>\n",
       "      <td>1.0836</td>\n",
       "      <td>514.0070</td>\n",
       "      <td>783.8335</td>\n",
       "      <td>...</td>\n",
       "      <td>411.3501</td>\n",
       "      <td>335.5674</td>\n",
       "      <td>96.0828</td>\n",
       "      <td>561.6872</td>\n",
       "      <td>1395.7294</td>\n",
       "      <td>50.5699</td>\n",
       "      <td>1116.1500</td>\n",
       "      <td>4323.0044</td>\n",
       "      <td>2009.7925</td>\n",
       "      <td>1151.9102</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00018</th>\n",
       "      <td>498.7862</td>\n",
       "      <td>250.2883</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>6228.5266</td>\n",
       "      <td>19.4551</td>\n",
       "      <td>6.4834</td>\n",
       "      <td>154.6036</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>1132.0976</td>\n",
       "      <td>1054.7958</td>\n",
       "      <td>...</td>\n",
       "      <td>684.1710</td>\n",
       "      <td>1164.0158</td>\n",
       "      <td>77.3018</td>\n",
       "      <td>540.1153</td>\n",
       "      <td>1191.9442</td>\n",
       "      <td>345.6139</td>\n",
       "      <td>838.3507</td>\n",
       "      <td>2721.5227</td>\n",
       "      <td>1247.8010</td>\n",
       "      <td>1093.1973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00019</th>\n",
       "      <td>78.1975</td>\n",
       "      <td>129.2912</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>17460.6102</td>\n",
       "      <td>49.9119</td>\n",
       "      <td>2.2358</td>\n",
       "      <td>382.6354</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>642.3037</td>\n",
       "      <td>925.6073</td>\n",
       "      <td>...</td>\n",
       "      <td>378.9784</td>\n",
       "      <td>493.4656</td>\n",
       "      <td>86.5561</td>\n",
       "      <td>2508.5298</td>\n",
       "      <td>997.7906</td>\n",
       "      <td>12.7758</td>\n",
       "      <td>538.8197</td>\n",
       "      <td>2842.2978</td>\n",
       "      <td>791.7807</td>\n",
       "      <td>655.0795</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00020</th>\n",
       "      <td>77.9087</td>\n",
       "      <td>106.2513</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>9805.9392</td>\n",
       "      <td>13.4124</td>\n",
       "      <td>0.3426</td>\n",
       "      <td>220.9714</td>\n",
       "      <td>2.0555</td>\n",
       "      <td>607.7570</td>\n",
       "      <td>1069.9126</td>\n",
       "      <td>...</td>\n",
       "      <td>629.6931</td>\n",
       "      <td>1674.2436</td>\n",
       "      <td>76.3979</td>\n",
       "      <td>687.9233</td>\n",
       "      <td>1172.3474</td>\n",
       "      <td>178.8327</td>\n",
       "      <td>1260.0508</td>\n",
       "      <td>2124.7512</td>\n",
       "      <td>1417.9854</td>\n",
       "      <td>1018.5239</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>normal</th>\n",
       "      <th>files\\S_00021</th>\n",
       "      <td>19.0722</td>\n",
       "      <td>33.5206</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>41867.0567</td>\n",
       "      <td>72.6340</td>\n",
       "      <td>9.7938</td>\n",
       "      <td>648.4536</td>\n",
       "      <td>3.0928</td>\n",
       "      <td>557.2165</td>\n",
       "      <td>1265.4639</td>\n",
       "      <td>...</td>\n",
       "      <td>216.1701</td>\n",
       "      <td>156.1856</td>\n",
       "      <td>75.7732</td>\n",
       "      <td>380.4124</td>\n",
       "      <td>1036.5979</td>\n",
       "      <td>0.5155</td>\n",
       "      <td>1453.0928</td>\n",
       "      <td>4177.3196</td>\n",
       "      <td>1769.5876</td>\n",
       "      <td>664.4330</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th rowspan=\"2\" valign=\"top\">tumoral</th>\n",
       "      <th>files\\S_00022</th>\n",
       "      <td>106.6447</td>\n",
       "      <td>131.5072</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>6882.3774</td>\n",
       "      <td>29.1059</td>\n",
       "      <td>48.4450</td>\n",
       "      <td>248.8038</td>\n",
       "      <td>0.5981</td>\n",
       "      <td>755.9809</td>\n",
       "      <td>1429.7249</td>\n",
       "      <td>...</td>\n",
       "      <td>352.3834</td>\n",
       "      <td>916.5670</td>\n",
       "      <td>128.2895</td>\n",
       "      <td>889.9522</td>\n",
       "      <td>1225.1794</td>\n",
       "      <td>330.1435</td>\n",
       "      <td>933.3134</td>\n",
       "      <td>2473.9833</td>\n",
       "      <td>1159.0909</td>\n",
       "      <td>1291.2679</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00023</th>\n",
       "      <td>104.6192</td>\n",
       "      <td>134.1636</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>5761.7285</td>\n",
       "      <td>27.3077</td>\n",
       "      <td>0.6274</td>\n",
       "      <td>301.7803</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>388.9891</td>\n",
       "      <td>1365.2263</td>\n",
       "      <td>...</td>\n",
       "      <td>433.0986</td>\n",
       "      <td>975.6098</td>\n",
       "      <td>95.3651</td>\n",
       "      <td>963.3754</td>\n",
       "      <td>1550.3098</td>\n",
       "      <td>210.4933</td>\n",
       "      <td>1081.9544</td>\n",
       "      <td>1399.1060</td>\n",
       "      <td>822.5237</td>\n",
       "      <td>1145.0082</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>normal</th>\n",
       "      <th>files\\S_00024</th>\n",
       "      <td>49.2346</td>\n",
       "      <td>105.1292</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>33165.7199</td>\n",
       "      <td>88.5257</td>\n",
       "      <td>105.5870</td>\n",
       "      <td>202.0674</td>\n",
       "      <td>0.9845</td>\n",
       "      <td>474.5262</td>\n",
       "      <td>1009.5988</td>\n",
       "      <td>...</td>\n",
       "      <td>455.9685</td>\n",
       "      <td>301.0091</td>\n",
       "      <td>101.6490</td>\n",
       "      <td>698.4986</td>\n",
       "      <td>1199.3601</td>\n",
       "      <td>108.7866</td>\n",
       "      <td>1570.7605</td>\n",
       "      <td>3515.6288</td>\n",
       "      <td>1821.5604</td>\n",
       "      <td>1427.5166</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th rowspan=\"9\" valign=\"top\">tumoral</th>\n",
       "      <th>files\\S_00025</th>\n",
       "      <td>408.9985</td>\n",
       "      <td>317.6138</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>4542.8757</td>\n",
       "      <td>14.1759</td>\n",
       "      <td>3.5381</td>\n",
       "      <td>107.3219</td>\n",
       "      <td>3.5381</td>\n",
       "      <td>759.1155</td>\n",
       "      <td>1739.5577</td>\n",
       "      <td>...</td>\n",
       "      <td>917.0162</td>\n",
       "      <td>2811.9902</td>\n",
       "      <td>84.5209</td>\n",
       "      <td>1226.5356</td>\n",
       "      <td>937.9853</td>\n",
       "      <td>291.3022</td>\n",
       "      <td>873.9066</td>\n",
       "      <td>2914.9877</td>\n",
       "      <td>845.6020</td>\n",
       "      <td>793.7101</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00026</th>\n",
       "      <td>28.4304</td>\n",
       "      <td>67.3590</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>11944.5988</td>\n",
       "      <td>92.6274</td>\n",
       "      <td>2.0429</td>\n",
       "      <td>59.6981</td>\n",
       "      <td>0.2270</td>\n",
       "      <td>826.9209</td>\n",
       "      <td>868.4599</td>\n",
       "      <td>...</td>\n",
       "      <td>1259.4530</td>\n",
       "      <td>803.5410</td>\n",
       "      <td>130.9726</td>\n",
       "      <td>1237.3170</td>\n",
       "      <td>1506.5259</td>\n",
       "      <td>70.8206</td>\n",
       "      <td>1251.8443</td>\n",
       "      <td>1570.7638</td>\n",
       "      <td>2434.2299</td>\n",
       "      <td>875.7235</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00027</th>\n",
       "      <td>134.9986</td>\n",
       "      <td>156.4523</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>7612.7283</td>\n",
       "      <td>27.9545</td>\n",
       "      <td>6.5434</td>\n",
       "      <td>199.7155</td>\n",
       "      <td>0.5690</td>\n",
       "      <td>925.4623</td>\n",
       "      <td>2222.1906</td>\n",
       "      <td>...</td>\n",
       "      <td>453.9403</td>\n",
       "      <td>620.4836</td>\n",
       "      <td>80.5121</td>\n",
       "      <td>623.8976</td>\n",
       "      <td>1239.5448</td>\n",
       "      <td>193.1721</td>\n",
       "      <td>1040.1138</td>\n",
       "      <td>2066.8563</td>\n",
       "      <td>1434.4239</td>\n",
       "      <td>902.9872</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00028</th>\n",
       "      <td>189.4169</td>\n",
       "      <td>139.7979</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>15693.0656</td>\n",
       "      <td>29.1423</td>\n",
       "      <td>5.4418</td>\n",
       "      <td>189.4273</td>\n",
       "      <td>1.2957</td>\n",
       "      <td>644.7266</td>\n",
       "      <td>909.3029</td>\n",
       "      <td>...</td>\n",
       "      <td>386.7686</td>\n",
       "      <td>312.5162</td>\n",
       "      <td>89.1423</td>\n",
       "      <td>575.2786</td>\n",
       "      <td>1146.1519</td>\n",
       "      <td>103.6538</td>\n",
       "      <td>868.3597</td>\n",
       "      <td>4629.1785</td>\n",
       "      <td>1646.7997</td>\n",
       "      <td>1048.1990</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00029</th>\n",
       "      <td>104.2612</td>\n",
       "      <td>112.4857</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>34667.9763</td>\n",
       "      <td>53.2913</td>\n",
       "      <td>3.0546</td>\n",
       "      <td>475.3723</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>686.1397</td>\n",
       "      <td>1687.6670</td>\n",
       "      <td>...</td>\n",
       "      <td>334.0512</td>\n",
       "      <td>669.7213</td>\n",
       "      <td>90.1107</td>\n",
       "      <td>1037.8007</td>\n",
       "      <td>1076.3650</td>\n",
       "      <td>124.4750</td>\n",
       "      <td>1217.2585</td>\n",
       "      <td>2527.3005</td>\n",
       "      <td>923.6350</td>\n",
       "      <td>767.0867</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01188</th>\n",
       "      <td>101.1541</td>\n",
       "      <td>134.2876</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>10181.7311</td>\n",
       "      <td>203.8266</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>31.5925</td>\n",
       "      <td>0.6447</td>\n",
       "      <td>724.0490</td>\n",
       "      <td>1119.9226</td>\n",
       "      <td>...</td>\n",
       "      <td>307.0664</td>\n",
       "      <td>575.7576</td>\n",
       "      <td>136.0413</td>\n",
       "      <td>1113.1528</td>\n",
       "      <td>2042.2308</td>\n",
       "      <td>27.4017</td>\n",
       "      <td>1385.2353</td>\n",
       "      <td>1067.3759</td>\n",
       "      <td>2440.0387</td>\n",
       "      <td>1277.2405</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01189</th>\n",
       "      <td>198.8155</td>\n",
       "      <td>134.2182</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>17129.4172</td>\n",
       "      <td>27.7812</td>\n",
       "      <td>5.0404</td>\n",
       "      <td>282.6840</td>\n",
       "      <td>4.2004</td>\n",
       "      <td>622.4929</td>\n",
       "      <td>831.6707</td>\n",
       "      <td>...</td>\n",
       "      <td>430.3350</td>\n",
       "      <td>319.6472</td>\n",
       "      <td>50.4043</td>\n",
       "      <td>328.4679</td>\n",
       "      <td>1004.7254</td>\n",
       "      <td>96.1882</td>\n",
       "      <td>546.4664</td>\n",
       "      <td>9633.5188</td>\n",
       "      <td>1265.9876</td>\n",
       "      <td>661.5562</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01190</th>\n",
       "      <td>36.3125</td>\n",
       "      <td>63.4694</td>\n",
       "      <td>0.3519</td>\n",
       "      <td>7903.5749</td>\n",
       "      <td>11.2738</td>\n",
       "      <td>56.6502</td>\n",
       "      <td>125.2639</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>287.8255</td>\n",
       "      <td>1047.8536</td>\n",
       "      <td>...</td>\n",
       "      <td>417.2343</td>\n",
       "      <td>1169.5989</td>\n",
       "      <td>81.9845</td>\n",
       "      <td>830.4011</td>\n",
       "      <td>1260.3800</td>\n",
       "      <td>603.8001</td>\n",
       "      <td>2003.1668</td>\n",
       "      <td>876.1436</td>\n",
       "      <td>929.9789</td>\n",
       "      <td>1127.0232</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>normal</th>\n",
       "      <th>files\\S_01191</th>\n",
       "      <td>103.0203</td>\n",
       "      <td>149.4418</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>26732.5545</td>\n",
       "      <td>42.7705</td>\n",
       "      <td>53.9638</td>\n",
       "      <td>249.5826</td>\n",
       "      <td>0.4216</td>\n",
       "      <td>695.6272</td>\n",
       "      <td>1029.5283</td>\n",
       "      <td>...</td>\n",
       "      <td>194.3540</td>\n",
       "      <td>163.9994</td>\n",
       "      <td>90.6423</td>\n",
       "      <td>496.6357</td>\n",
       "      <td>1244.9620</td>\n",
       "      <td>27.8251</td>\n",
       "      <td>954.4849</td>\n",
       "      <td>8232.8538</td>\n",
       "      <td>1283.7485</td>\n",
       "      <td>1226.4119</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th rowspan=\"20\" valign=\"top\">tumoral</th>\n",
       "      <th>files\\S_01192</th>\n",
       "      <td>67.4286</td>\n",
       "      <td>149.3827</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>8850.8124</td>\n",
       "      <td>18.1266</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>39.7791</td>\n",
       "      <td>0.3014</td>\n",
       "      <td>584.3314</td>\n",
       "      <td>1814.7724</td>\n",
       "      <td>...</td>\n",
       "      <td>679.1082</td>\n",
       "      <td>1165.0465</td>\n",
       "      <td>81.9691</td>\n",
       "      <td>702.4634</td>\n",
       "      <td>1074.9407</td>\n",
       "      <td>40.0805</td>\n",
       "      <td>1094.8303</td>\n",
       "      <td>1557.1121</td>\n",
       "      <td>1870.8248</td>\n",
       "      <td>854.6487</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01193</th>\n",
       "      <td>205.0052</td>\n",
       "      <td>230.4302</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>16641.0205</td>\n",
       "      <td>34.8463</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>256.9871</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>885.0748</td>\n",
       "      <td>1174.9971</td>\n",
       "      <td>...</td>\n",
       "      <td>348.2500</td>\n",
       "      <td>563.6090</td>\n",
       "      <td>38.0378</td>\n",
       "      <td>502.8412</td>\n",
       "      <td>764.0032</td>\n",
       "      <td>150.7596</td>\n",
       "      <td>709.7298</td>\n",
       "      <td>3551.4322</td>\n",
       "      <td>608.1410</td>\n",
       "      <td>841.0066</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01194</th>\n",
       "      <td>231.0080</td>\n",
       "      <td>131.8916</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>13194.3494</td>\n",
       "      <td>16.4940</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>97.5904</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>912.8514</td>\n",
       "      <td>1278.3133</td>\n",
       "      <td>...</td>\n",
       "      <td>1233.3012</td>\n",
       "      <td>1849.3976</td>\n",
       "      <td>61.8474</td>\n",
       "      <td>877.5100</td>\n",
       "      <td>959.0361</td>\n",
       "      <td>38.5542</td>\n",
       "      <td>839.7590</td>\n",
       "      <td>5763.0522</td>\n",
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       "      <td>630.5221</td>\n",
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       "      <th>files\\S_01195</th>\n",
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       "      <td>12.6392</td>\n",
       "      <td>1.6019</td>\n",
       "      <td>93.7125</td>\n",
       "      <td>0.4005</td>\n",
       "      <td>840.2082</td>\n",
       "      <td>994.3933</td>\n",
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       "      <td>1094.6115</td>\n",
       "      <td>1755.5066</td>\n",
       "      <td>67.8815</td>\n",
       "      <td>681.2175</td>\n",
       "      <td>1225.2703</td>\n",
       "      <td>214.4573</td>\n",
       "      <td>662.3949</td>\n",
       "      <td>2621.7461</td>\n",
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       "      <td>721.8662</td>\n",
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       "      <th>files\\S_01196</th>\n",
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       "      <td>11.4234</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>446.6874</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>951.8634</td>\n",
       "      <td>575.5694</td>\n",
       "      <td>...</td>\n",
       "      <td>306.9358</td>\n",
       "      <td>577.6398</td>\n",
       "      <td>60.0414</td>\n",
       "      <td>720.4969</td>\n",
       "      <td>1129.9172</td>\n",
       "      <td>13.9752</td>\n",
       "      <td>679.0890</td>\n",
       "      <td>4408.9027</td>\n",
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       "      <td>952.8986</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01197</th>\n",
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       "      <td>7032.0082</td>\n",
       "      <td>15.2654</td>\n",
       "      <td>0.2418</td>\n",
       "      <td>142.1835</td>\n",
       "      <td>0.7254</td>\n",
       "      <td>641.5186</td>\n",
       "      <td>1112.5620</td>\n",
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       "      <td>486.2121</td>\n",
       "      <td>965.7841</td>\n",
       "      <td>51.5053</td>\n",
       "      <td>1471.1643</td>\n",
       "      <td>1595.4540</td>\n",
       "      <td>10.8814</td>\n",
       "      <td>954.1772</td>\n",
       "      <td>2799.6615</td>\n",
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       "      <td>1121.2671</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01198</th>\n",
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       "      <td>4946.4883</td>\n",
       "      <td>6.4409</td>\n",
       "      <td>0.3386</td>\n",
       "      <td>67.3891</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>615.3065</td>\n",
       "      <td>699.2889</td>\n",
       "      <td>...</td>\n",
       "      <td>337.2469</td>\n",
       "      <td>264.4768</td>\n",
       "      <td>65.0186</td>\n",
       "      <td>601.7609</td>\n",
       "      <td>1771.4189</td>\n",
       "      <td>80.9346</td>\n",
       "      <td>1303.0816</td>\n",
       "      <td>2557.3993</td>\n",
       "      <td>1781.2394</td>\n",
       "      <td>1158.8215</td>\n",
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       "      <th>files\\S_01199</th>\n",
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       "      <td>19459.9708</td>\n",
       "      <td>18.1169</td>\n",
       "      <td>1.5936</td>\n",
       "      <td>295.3519</td>\n",
       "      <td>0.5312</td>\n",
       "      <td>504.6481</td>\n",
       "      <td>1625.7636</td>\n",
       "      <td>...</td>\n",
       "      <td>352.8738</td>\n",
       "      <td>465.8699</td>\n",
       "      <td>51.2616</td>\n",
       "      <td>362.0186</td>\n",
       "      <td>1131.4741</td>\n",
       "      <td>2.6560</td>\n",
       "      <td>803.1873</td>\n",
       "      <td>6243.5591</td>\n",
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       "      <td>538.9110</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01200</th>\n",
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       "      <td>5481.4429</td>\n",
       "      <td>10.3015</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>120.3637</td>\n",
       "      <td>0.9572</td>\n",
       "      <td>819.5741</td>\n",
       "      <td>763.5798</td>\n",
       "      <td>...</td>\n",
       "      <td>594.9892</td>\n",
       "      <td>1809.7631</td>\n",
       "      <td>155.5396</td>\n",
       "      <td>1938.0235</td>\n",
       "      <td>1022.9720</td>\n",
       "      <td>190.4762</td>\n",
       "      <td>992.1034</td>\n",
       "      <td>1865.5181</td>\n",
       "      <td>1347.4515</td>\n",
       "      <td>1465.9009</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01201</th>\n",
       "      <td>35.0230</td>\n",
       "      <td>40.6498</td>\n",
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       "      <td>16361.7097</td>\n",
       "      <td>23.0829</td>\n",
       "      <td>384.7926</td>\n",
       "      <td>222.5806</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>396.3134</td>\n",
       "      <td>871.4286</td>\n",
       "      <td>...</td>\n",
       "      <td>289.2995</td>\n",
       "      <td>1144.7005</td>\n",
       "      <td>37.7880</td>\n",
       "      <td>252.5346</td>\n",
       "      <td>732.7189</td>\n",
       "      <td>133.6406</td>\n",
       "      <td>800.9217</td>\n",
       "      <td>8333.6406</td>\n",
       "      <td>810.1382</td>\n",
       "      <td>835.4839</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01202</th>\n",
       "      <td>137.2796</td>\n",
       "      <td>191.7680</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>15847.2183</td>\n",
       "      <td>16.0537</td>\n",
       "      <td>3037.2466</td>\n",
       "      <td>147.1004</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>353.6068</td>\n",
       "      <td>636.4922</td>\n",
       "      <td>...</td>\n",
       "      <td>799.9953</td>\n",
       "      <td>982.0839</td>\n",
       "      <td>52.8053</td>\n",
       "      <td>456.3885</td>\n",
       "      <td>1214.0500</td>\n",
       "      <td>205.5634</td>\n",
       "      <td>1025.9312</td>\n",
       "      <td>4735.9736</td>\n",
       "      <td>806.6950</td>\n",
       "      <td>727.4870</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01203</th>\n",
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       "      <td>8260.9638</td>\n",
       "      <td>22.1878</td>\n",
       "      <td>1.7587</td>\n",
       "      <td>181.8502</td>\n",
       "      <td>0.3517</td>\n",
       "      <td>772.4235</td>\n",
       "      <td>718.2554</td>\n",
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       "      <td>745.5786</td>\n",
       "      <td>2321.8431</td>\n",
       "      <td>138.9377</td>\n",
       "      <td>1128.7372</td>\n",
       "      <td>1333.8023</td>\n",
       "      <td>159.6905</td>\n",
       "      <td>861.4140</td>\n",
       "      <td>2645.4450</td>\n",
       "      <td>272.9511</td>\n",
       "      <td>521.2803</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01204</th>\n",
       "      <td>112.2456</td>\n",
       "      <td>240.4453</td>\n",
       "      <td>0.2516</td>\n",
       "      <td>8443.0218</td>\n",
       "      <td>18.6715</td>\n",
       "      <td>1.0064</td>\n",
       "      <td>484.5893</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>726.1291</td>\n",
       "      <td>1942.1311</td>\n",
       "      <td>...</td>\n",
       "      <td>235.6699</td>\n",
       "      <td>1034.0923</td>\n",
       "      <td>56.3593</td>\n",
       "      <td>673.0406</td>\n",
       "      <td>1138.7596</td>\n",
       "      <td>57.8689</td>\n",
       "      <td>1028.3054</td>\n",
       "      <td>3036.6084</td>\n",
       "      <td>1091.9613</td>\n",
       "      <td>1030.0667</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01205</th>\n",
       "      <td>199.4404</td>\n",
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       "      <td>6768.3049</td>\n",
       "      <td>29.7486</td>\n",
       "      <td>0.8110</td>\n",
       "      <td>779.3998</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>714.9230</td>\n",
       "      <td>2165.0446</td>\n",
       "      <td>...</td>\n",
       "      <td>336.3869</td>\n",
       "      <td>517.4371</td>\n",
       "      <td>58.7997</td>\n",
       "      <td>489.0511</td>\n",
       "      <td>947.6886</td>\n",
       "      <td>5.6772</td>\n",
       "      <td>835.3609</td>\n",
       "      <td>3729.9270</td>\n",
       "      <td>1327.2506</td>\n",
       "      <td>761.9627</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01206</th>\n",
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       "      <td>225.8155</td>\n",
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       "      <td>2269.1737</td>\n",
       "      <td>21.4821</td>\n",
       "      <td>0.4804</td>\n",
       "      <td>54.2878</td>\n",
       "      <td>0.2402</td>\n",
       "      <td>888.0615</td>\n",
       "      <td>2086.4761</td>\n",
       "      <td>...</td>\n",
       "      <td>289.3418</td>\n",
       "      <td>770.1177</td>\n",
       "      <td>72.3036</td>\n",
       "      <td>580.5909</td>\n",
       "      <td>1220.2738</td>\n",
       "      <td>19.9375</td>\n",
       "      <td>1097.5258</td>\n",
       "      <td>1017.7756</td>\n",
       "      <td>2648.5707</td>\n",
       "      <td>1828.2489</td>\n",
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       "      <th>files\\S_01207</th>\n",
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       "      <td>180.9173</td>\n",
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       "      <td>4369.9548</td>\n",
       "      <td>24.1021</td>\n",
       "      <td>427.6486</td>\n",
       "      <td>483.8501</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>1072.9974</td>\n",
       "      <td>1052.9716</td>\n",
       "      <td>...</td>\n",
       "      <td>253.6693</td>\n",
       "      <td>786.1757</td>\n",
       "      <td>10.9819</td>\n",
       "      <td>101.4212</td>\n",
       "      <td>1323.6434</td>\n",
       "      <td>99.4832</td>\n",
       "      <td>475.4522</td>\n",
       "      <td>4866.9251</td>\n",
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       "      <td>536.8217</td>\n",
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       "      <th>files\\S_01208</th>\n",
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       "      <td>21885.9105</td>\n",
       "      <td>16.8015</td>\n",
       "      <td>3.0133</td>\n",
       "      <td>128.7129</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>746.8790</td>\n",
       "      <td>1028.8420</td>\n",
       "      <td>...</td>\n",
       "      <td>1324.6061</td>\n",
       "      <td>456.7370</td>\n",
       "      <td>54.6707</td>\n",
       "      <td>517.8648</td>\n",
       "      <td>1085.6651</td>\n",
       "      <td>20.2325</td>\n",
       "      <td>910.0301</td>\n",
       "      <td>3315.5402</td>\n",
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       "      <td>1085.2346</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01209</th>\n",
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       "      <td>8626.3960</td>\n",
       "      <td>21.9488</td>\n",
       "      <td>40.5996</td>\n",
       "      <td>92.4422</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>555.9026</td>\n",
       "      <td>2840.7245</td>\n",
       "      <td>...</td>\n",
       "      <td>1043.4916</td>\n",
       "      <td>2266.0837</td>\n",
       "      <td>49.3442</td>\n",
       "      <td>540.9119</td>\n",
       "      <td>616.4897</td>\n",
       "      <td>131.7926</td>\n",
       "      <td>689.5690</td>\n",
       "      <td>2394.7533</td>\n",
       "      <td>1180.5122</td>\n",
       "      <td>823.8601</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01210</th>\n",
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       "      <td>7952.8999</td>\n",
       "      <td>8.3485</td>\n",
       "      <td>86.0858</td>\n",
       "      <td>233.2900</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>894.9285</td>\n",
       "      <td>1288.6866</td>\n",
       "      <td>...</td>\n",
       "      <td>778.3459</td>\n",
       "      <td>1576.5930</td>\n",
       "      <td>82.9649</td>\n",
       "      <td>664.2393</td>\n",
       "      <td>1505.8518</td>\n",
       "      <td>110.0130</td>\n",
       "      <td>737.5813</td>\n",
       "      <td>2076.4629</td>\n",
       "      <td>1600.7802</td>\n",
       "      <td>867.6203</td>\n",
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       "      <th>files\\S_01211</th>\n",
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       "      <td>4794.4997</td>\n",
       "      <td>14.9107</td>\n",
       "      <td>0.5956</td>\n",
       "      <td>522.0369</td>\n",
       "      <td>0.5956</td>\n",
       "      <td>427.3377</td>\n",
       "      <td>592.9124</td>\n",
       "      <td>...</td>\n",
       "      <td>475.8279</td>\n",
       "      <td>570.5777</td>\n",
       "      <td>38.7135</td>\n",
       "      <td>738.2370</td>\n",
       "      <td>765.6343</td>\n",
       "      <td>148.6004</td>\n",
       "      <td>1208.4574</td>\n",
       "      <td>4396.6647</td>\n",
       "      <td>288.5646</td>\n",
       "      <td>671.8285</td>\n",
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       "    <tr>\n",
       "      <th>normal</th>\n",
       "      <th>files\\S_01212</th>\n",
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       "      <td>0.0000</td>\n",
       "      <td>53114.9853</td>\n",
       "      <td>59.9410</td>\n",
       "      <td>5.0147</td>\n",
       "      <td>723.8938</td>\n",
       "      <td>1.4749</td>\n",
       "      <td>507.3746</td>\n",
       "      <td>1303.5398</td>\n",
       "      <td>...</td>\n",
       "      <td>208.8053</td>\n",
       "      <td>110.9145</td>\n",
       "      <td>83.4808</td>\n",
       "      <td>461.6519</td>\n",
       "      <td>1135.9882</td>\n",
       "      <td>17.6991</td>\n",
       "      <td>1331.5634</td>\n",
       "      <td>4989.6755</td>\n",
       "      <td>1836.8732</td>\n",
       "      <td>998.8201</td>\n",
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       "    <tr>\n",
       "      <th rowspan=\"5\" valign=\"top\">tumoral</th>\n",
       "      <th>files\\S_01213</th>\n",
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       "      <td>180.5188</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>15451.6458</td>\n",
       "      <td>28.2290</td>\n",
       "      <td>1.3417</td>\n",
       "      <td>659.6601</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>513.4168</td>\n",
       "      <td>612.7013</td>\n",
       "      <td>...</td>\n",
       "      <td>528.0635</td>\n",
       "      <td>339.8927</td>\n",
       "      <td>80.5009</td>\n",
       "      <td>601.5206</td>\n",
       "      <td>1011.6279</td>\n",
       "      <td>37.1199</td>\n",
       "      <td>823.7925</td>\n",
       "      <td>4295.1699</td>\n",
       "      <td>1004.0250</td>\n",
       "      <td>913.2379</td>\n",
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       "      <th>files\\S_01214</th>\n",
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       "      <td>62.1985</td>\n",
       "      <td>0.3057</td>\n",
       "      <td>12046.1697</td>\n",
       "      <td>41.0428</td>\n",
       "      <td>450.9355</td>\n",
       "      <td>121.3704</td>\n",
       "      <td>0.3057</td>\n",
       "      <td>402.9377</td>\n",
       "      <td>586.0633</td>\n",
       "      <td>...</td>\n",
       "      <td>551.4131</td>\n",
       "      <td>756.6545</td>\n",
       "      <td>62.0610</td>\n",
       "      <td>733.1142</td>\n",
       "      <td>820.2441</td>\n",
       "      <td>188.0172</td>\n",
       "      <td>1443.2994</td>\n",
       "      <td>2548.1679</td>\n",
       "      <td>706.8223</td>\n",
       "      <td>1868.2489</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01215</th>\n",
       "      <td>115.6844</td>\n",
       "      <td>127.5295</td>\n",
       "      <td>0.3043</td>\n",
       "      <td>13477.5044</td>\n",
       "      <td>66.4354</td>\n",
       "      <td>0.6087</td>\n",
       "      <td>62.3906</td>\n",
       "      <td>0.3043</td>\n",
       "      <td>546.6028</td>\n",
       "      <td>552.0810</td>\n",
       "      <td>...</td>\n",
       "      <td>462.7406</td>\n",
       "      <td>283.6491</td>\n",
       "      <td>87.0425</td>\n",
       "      <td>665.6015</td>\n",
       "      <td>1275.2035</td>\n",
       "      <td>68.4775</td>\n",
       "      <td>1575.5916</td>\n",
       "      <td>2623.4497</td>\n",
       "      <td>838.1648</td>\n",
       "      <td>2056.7603</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01216</th>\n",
       "      <td>270.0507</td>\n",
       "      <td>218.2355</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>25304.6523</td>\n",
       "      <td>33.9065</td>\n",
       "      <td>10.1297</td>\n",
       "      <td>451.6447</td>\n",
       "      <td>0.3493</td>\n",
       "      <td>658.7795</td>\n",
       "      <td>1375.1934</td>\n",
       "      <td>...</td>\n",
       "      <td>496.5367</td>\n",
       "      <td>604.6380</td>\n",
       "      <td>30.7384</td>\n",
       "      <td>451.9940</td>\n",
       "      <td>906.7824</td>\n",
       "      <td>10.8283</td>\n",
       "      <td>608.4803</td>\n",
       "      <td>3680.2230</td>\n",
       "      <td>960.5745</td>\n",
       "      <td>780.6851</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01217</th>\n",
       "      <td>315.0663</td>\n",
       "      <td>290.0399</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>5901.0304</td>\n",
       "      <td>27.4647</td>\n",
       "      <td>8.8733</td>\n",
       "      <td>554.7716</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>811.7104</td>\n",
       "      <td>1345.2634</td>\n",
       "      <td>...</td>\n",
       "      <td>283.8363</td>\n",
       "      <td>442.8914</td>\n",
       "      <td>60.5696</td>\n",
       "      <td>601.0669</td>\n",
       "      <td>1128.0614</td>\n",
       "      <td>27.3914</td>\n",
       "      <td>927.4486</td>\n",
       "      <td>2272.3261</td>\n",
       "      <td>1197.5043</td>\n",
       "      <td>641.5753</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>1218 rows × 20207 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                              normalized_count            \\\n",
       "gene_symbol                                               A1BG  A1BG-AS1   \n",
       "manually_curated__tissue_status sample                                     \n",
       "tumoral                         files\\S_00000         216.9506  214.4831   \n",
       "                                files\\S_00001         128.9070  183.4258   \n",
       "                                files\\S_00002         161.2486  100.7430   \n",
       "                                files\\S_00003         127.1454  127.8283   \n",
       "                                files\\S_00004          74.5163  141.5685   \n",
       "                                files\\S_00005         341.4830  155.5912   \n",
       "                                files\\S_00006         180.3284  109.5081   \n",
       "                                files\\S_00007         101.3246  120.9196   \n",
       "                                files\\S_00008         117.7966   73.5508   \n",
       "                                files\\S_00009         192.7825  251.1441   \n",
       "                                files\\S_00010          49.1992   75.0039   \n",
       "                                files\\S_00011         222.6672  175.3532   \n",
       "                                files\\S_00012         220.4913  269.9923   \n",
       "                                files\\S_00013         100.5562  130.1150   \n",
       "                                files\\S_00014         616.6585  180.1730   \n",
       "normal                          files\\S_00015          80.8742  128.5481   \n",
       "tumoral                         files\\S_00016         142.8677   88.0352   \n",
       "                                files\\S_00017         111.3007  126.4392   \n",
       "                                files\\S_00018         498.7862  250.2883   \n",
       "                                files\\S_00019          78.1975  129.2912   \n",
       "                                files\\S_00020          77.9087  106.2513   \n",
       "normal                          files\\S_00021          19.0722   33.5206   \n",
       "tumoral                         files\\S_00022         106.6447  131.5072   \n",
       "                                files\\S_00023         104.6192  134.1636   \n",
       "normal                          files\\S_00024          49.2346  105.1292   \n",
       "tumoral                         files\\S_00025         408.9985  317.6138   \n",
       "                                files\\S_00026          28.4304   67.3590   \n",
       "                                files\\S_00027         134.9986  156.4523   \n",
       "                                files\\S_00028         189.4169  139.7979   \n",
       "                                files\\S_00029         104.2612  112.4857   \n",
       "...                                                        ...       ...   \n",
       "                                files\\S_01188         101.1541  134.2876   \n",
       "                                files\\S_01189         198.8155  134.2182   \n",
       "                                files\\S_01190          36.3125   63.4694   \n",
       "normal                          files\\S_01191         103.0203  149.4418   \n",
       "tumoral                         files\\S_01192          67.4286  149.3827   \n",
       "                                files\\S_01193         205.0052  230.4302   \n",
       "                                files\\S_01194         231.0080  131.8916   \n",
       "                                files\\S_01195          74.6616  102.5811   \n",
       "                                files\\S_01196         462.6501  347.1687   \n",
       "                                files\\S_01197         130.9902  153.8508   \n",
       "                                files\\S_01198          96.4748  135.7230   \n",
       "                                files\\S_01199         139.5113  180.9456   \n",
       "                                files\\S_01200         124.5250   82.1632   \n",
       "                                files\\S_01201          35.0230   40.6498   \n",
       "                                files\\S_01202         137.2796  191.7680   \n",
       "                                files\\S_01203          85.1178  151.8677   \n",
       "                                files\\S_01204         112.2456  240.4453   \n",
       "                                files\\S_01205         199.4404  123.4023   \n",
       "                                files\\S_01206         151.3668  225.8155   \n",
       "                                files\\S_01207         563.9018  180.9173   \n",
       "                                files\\S_01208         159.2768   98.3943   \n",
       "                                files\\S_01209          62.4047   38.9944   \n",
       "                                files\\S_01210         191.3550  137.4746   \n",
       "                                files\\S_01211          83.0554  140.0506   \n",
       "normal                          files\\S_01212          33.0383   99.5723   \n",
       "tumoral                         files\\S_01213         205.5411  180.5188   \n",
       "                                files\\S_01214          30.8776   62.1985   \n",
       "                                files\\S_01215         115.6844  127.5295   \n",
       "                                files\\S_01216         270.0507  218.2355   \n",
       "                                files\\S_01217         315.0663  290.0399   \n",
       "\n",
       "                                                                             \\\n",
       "gene_symbol                                      A1CF         A2M   A2M-AS1   \n",
       "manually_curated__tissue_status sample                                        \n",
       "tumoral                         files\\S_00000  0.0000   4648.3610   28.5221   \n",
       "                                files\\S_00001  0.4078  14028.9356   15.5179   \n",
       "                                files\\S_00002  0.0000  17754.2889   23.3321   \n",
       "                                files\\S_00003  0.0000   9604.5625   22.4744   \n",
       "                                files\\S_00004  0.0000  11410.8522   25.1297   \n",
       "                                files\\S_00005  0.0000   2512.5972   13.2545   \n",
       "                                files\\S_00006  0.0000  28739.2847   55.5089   \n",
       "                                files\\S_00007  0.0000   8586.3106   24.0443   \n",
       "                                files\\S_00008  0.0000   9871.0847   11.9661   \n",
       "                                files\\S_00009  0.0000   9226.3842   15.1412   \n",
       "                                files\\S_00010  0.0000  31626.9490   28.4176   \n",
       "                                files\\S_00011  0.0000  10548.8553   36.7133   \n",
       "                                files\\S_00012  0.0000  28120.3800   36.4290   \n",
       "                                files\\S_00013  0.0000   8568.4645   18.1390   \n",
       "                                files\\S_00014  0.0000   7832.7832   16.7374   \n",
       "normal                          files\\S_00015  0.0000  25382.8067   68.6247   \n",
       "tumoral                         files\\S_00016  0.0000   8592.7825   26.1840   \n",
       "                                files\\S_00017  0.0000  29446.7761   39.4517   \n",
       "                                files\\S_00018  0.0000   6228.5266   19.4551   \n",
       "                                files\\S_00019  0.0000  17460.6102   49.9119   \n",
       "                                files\\S_00020  0.0000   9805.9392   13.4124   \n",
       "normal                          files\\S_00021  0.0000  41867.0567   72.6340   \n",
       "tumoral                         files\\S_00022  0.0000   6882.3774   29.1059   \n",
       "                                files\\S_00023  0.0000   5761.7285   27.3077   \n",
       "normal                          files\\S_00024  0.0000  33165.7199   88.5257   \n",
       "tumoral                         files\\S_00025  0.0000   4542.8757   14.1759   \n",
       "                                files\\S_00026  0.0000  11944.5988   92.6274   \n",
       "                                files\\S_00027  0.0000   7612.7283   27.9545   \n",
       "                                files\\S_00028  0.0000  15693.0656   29.1423   \n",
       "                                files\\S_00029  0.0000  34667.9763   53.2913   \n",
       "...                                               ...         ...       ...   \n",
       "                                files\\S_01188  0.0000  10181.7311  203.8266   \n",
       "                                files\\S_01189  0.0000  17129.4172   27.7812   \n",
       "                                files\\S_01190  0.3519   7903.5749   11.2738   \n",
       "normal                          files\\S_01191  0.0000  26732.5545   42.7705   \n",
       "tumoral                         files\\S_01192  0.0000   8850.8124   18.1266   \n",
       "                                files\\S_01193  0.0000  16641.0205   34.8463   \n",
       "                                files\\S_01194  0.0000  13194.3494   16.4940   \n",
       "                                files\\S_01195  0.0000   6185.1982   12.6392   \n",
       "                                files\\S_01196  0.5176  14337.4379   11.4234   \n",
       "                                files\\S_01197  0.0000   7032.0082   15.2654   \n",
       "                                files\\S_01198  0.0000   4946.4883    6.4409   \n",
       "                                files\\S_01199  0.0000  19459.9708   18.1169   \n",
       "                                files\\S_01200  0.0000   5481.4429   10.3015   \n",
       "                                files\\S_01201  0.0000  16361.7097   23.0829   \n",
       "                                files\\S_01202  0.0000  15847.2183   16.0537   \n",
       "                                files\\S_01203  0.0000   8260.9638   22.1878   \n",
       "                                files\\S_01204  0.2516   8443.0218   18.6715   \n",
       "                                files\\S_01205  0.0000   6768.3049   29.7486   \n",
       "                                files\\S_01206  0.0000   2269.1737   21.4821   \n",
       "                                files\\S_01207  0.0000   4369.9548   24.1021   \n",
       "                                files\\S_01208  0.0000  21885.9105   16.8015   \n",
       "                                files\\S_01209  0.0000   8626.3960   21.9488   \n",
       "                                files\\S_01210  0.0000   7952.8999    8.3485   \n",
       "                                files\\S_01211  0.0000   4794.4997   14.9107   \n",
       "normal                          files\\S_01212  0.0000  53114.9853   59.9410   \n",
       "tumoral                         files\\S_01213  0.0000  15451.6458   28.2290   \n",
       "                                files\\S_01214  0.3057  12046.1697   41.0428   \n",
       "                                files\\S_01215  0.3043  13477.5044   66.4354   \n",
       "                                files\\S_01216  0.0000  25304.6523   33.9065   \n",
       "                                files\\S_01217  0.0000   5901.0304   27.4647   \n",
       "\n",
       "                                                                             \\\n",
       "gene_symbol                                        A2ML1     A4GALT   A4GNT   \n",
       "manually_curated__tissue_status sample                                        \n",
       "tumoral                         files\\S_00000     1.0390   104.4156  0.0000   \n",
       "                                files\\S_00001     3.6705   183.9315  1.6313   \n",
       "                                files\\S_00002     0.0000   807.9038  0.0000   \n",
       "                                files\\S_00003     7.2420   209.3284  0.0000   \n",
       "                                files\\S_00004    25.1132   274.1869  4.5286   \n",
       "                                files\\S_00005     0.8016   521.0421  0.4008   \n",
       "                                files\\S_00006  3515.2196  2097.6779  0.9466   \n",
       "                                files\\S_00007     0.5210   252.4259  1.0420   \n",
       "                                files\\S_00008     5.0847   238.9831  0.0000   \n",
       "                                files\\S_00009     0.4708   291.4313  0.0000   \n",
       "                                files\\S_00010     3.1535   337.4254  0.9010   \n",
       "                                files\\S_00011     1.8889   202.8712  2.6445   \n",
       "                                files\\S_00012  2312.7621  1216.8108  1.3695   \n",
       "                                files\\S_00013     0.8364    97.0238  0.0000   \n",
       "                                files\\S_00014     0.5055   179.4552  0.0000   \n",
       "normal                          files\\S_00015    48.0573   512.7812  1.0225   \n",
       "tumoral                         files\\S_00016    27.2572   350.9370  0.5679   \n",
       "                                files\\S_00017    27.8134   263.3247  1.0836   \n",
       "                                files\\S_00018     6.4834   154.6036  0.0000   \n",
       "                                files\\S_00019     2.2358   382.6354  0.0000   \n",
       "                                files\\S_00020     0.3426   220.9714  2.0555   \n",
       "normal                          files\\S_00021     9.7938   648.4536  3.0928   \n",
       "tumoral                         files\\S_00022    48.4450   248.8038  0.5981   \n",
       "                                files\\S_00023     0.6274   301.7803  0.0000   \n",
       "normal                          files\\S_00024   105.5870   202.0674  0.9845   \n",
       "tumoral                         files\\S_00025     3.5381   107.3219  3.5381   \n",
       "                                files\\S_00026     2.0429    59.6981  0.2270   \n",
       "                                files\\S_00027     6.5434   199.7155  0.5690   \n",
       "                                files\\S_00028     5.4418   189.4273  1.2957   \n",
       "                                files\\S_00029     3.0546   475.3723  0.0000   \n",
       "...                                                  ...        ...     ...   \n",
       "                                files\\S_01188     0.0000    31.5925  0.6447   \n",
       "                                files\\S_01189     5.0404   282.6840  4.2004   \n",
       "                                files\\S_01190    56.6502   125.2639  0.0000   \n",
       "normal                          files\\S_01191    53.9638   249.5826  0.4216   \n",
       "tumoral                         files\\S_01192     0.0000    39.7791  0.3014   \n",
       "                                files\\S_01193     0.0000   256.9871  0.0000   \n",
       "                                files\\S_01194     0.0000    97.5904  0.0000   \n",
       "                                files\\S_01195     1.6019    93.7125  0.4005   \n",
       "                                files\\S_01196     0.0000   446.6874  0.0000   \n",
       "                                files\\S_01197     0.2418   142.1835  0.7254   \n",
       "                                files\\S_01198     0.3386    67.3891  0.0000   \n",
       "                                files\\S_01199     1.5936   295.3519  0.5312   \n",
       "                                files\\S_01200     0.0000   120.3637  0.9572   \n",
       "                                files\\S_01201   384.7926   222.5806  0.0000   \n",
       "                                files\\S_01202  3037.2466   147.1004  0.0000   \n",
       "                                files\\S_01203     1.7587   181.8502  0.3517   \n",
       "                                files\\S_01204     1.0064   484.5893  0.0000   \n",
       "                                files\\S_01205     0.8110   779.3998  0.0000   \n",
       "                                files\\S_01206     0.4804    54.2878  0.2402   \n",
       "                                files\\S_01207   427.6486   483.8501  0.0000   \n",
       "                                files\\S_01208     3.0133   128.7129  0.0000   \n",
       "                                files\\S_01209    40.5996    92.4422  0.0000   \n",
       "                                files\\S_01210    86.0858   233.2900  0.0000   \n",
       "                                files\\S_01211     0.5956   522.0369  0.5956   \n",
       "normal                          files\\S_01212     5.0147   723.8938  1.4749   \n",
       "tumoral                         files\\S_01213     1.3417   659.6601  0.0000   \n",
       "                                files\\S_01214   450.9355   121.3704  0.3057   \n",
       "                                files\\S_01215     0.6087    62.3906  0.3043   \n",
       "                                files\\S_01216    10.1297   451.6447  0.3493   \n",
       "                                files\\S_01217     8.8733   554.7716  0.0000   \n",
       "\n",
       "                                                                     \\\n",
       "gene_symbol                                         AAAS       AACS   \n",
       "manually_curated__tissue_status sample                                \n",
       "tumoral                         files\\S_00000   825.9740   741.5584   \n",
       "                                files\\S_00001   676.9984   855.6281   \n",
       "                                files\\S_00002   668.4097   919.9974   \n",
       "                                files\\S_00003   919.3896   781.1018   \n",
       "                                files\\S_00004   669.4113  1374.6398   \n",
       "                                files\\S_00005  1204.8096  1553.1062   \n",
       "                                files\\S_00006   566.0701  1144.9194   \n",
       "                                files\\S_00007   449.1045   767.4373   \n",
       "                                files\\S_00008   635.5932  1027.9661   \n",
       "                                files\\S_00009   686.4407  1049.9058   \n",
       "                                files\\S_00010   711.7919  2184.0297   \n",
       "                                files\\S_00011  1004.9112   576.1239   \n",
       "                                files\\S_00012   276.2989   636.4804   \n",
       "                                files\\S_00013   502.6835   505.1927   \n",
       "                                files\\S_00014   684.9627  1423.5091   \n",
       "normal                          files\\S_00015   535.7873   860.4294   \n",
       "tumoral                         files\\S_00016   563.3163   585.4628   \n",
       "                                files\\S_00017   514.0070   783.8335   \n",
       "                                files\\S_00018  1132.0976  1054.7958   \n",
       "                                files\\S_00019   642.3037   925.6073   \n",
       "                                files\\S_00020   607.7570  1069.9126   \n",
       "normal                          files\\S_00021   557.2165  1265.4639   \n",
       "tumoral                         files\\S_00022   755.9809  1429.7249   \n",
       "                                files\\S_00023   388.9891  1365.2263   \n",
       "normal                          files\\S_00024   474.5262  1009.5988   \n",
       "tumoral                         files\\S_00025   759.1155  1739.5577   \n",
       "                                files\\S_00026   826.9209   868.4599   \n",
       "                                files\\S_00027   925.4623  2222.1906   \n",
       "                                files\\S_00028   644.7266   909.3029   \n",
       "                                files\\S_00029   686.1397  1687.6670   \n",
       "...                                                  ...        ...   \n",
       "                                files\\S_01188   724.0490  1119.9226   \n",
       "                                files\\S_01189   622.4929   831.6707   \n",
       "                                files\\S_01190   287.8255  1047.8536   \n",
       "normal                          files\\S_01191   695.6272  1029.5283   \n",
       "tumoral                         files\\S_01192   584.3314  1814.7724   \n",
       "                                files\\S_01193   885.0748  1174.9971   \n",
       "                                files\\S_01194   912.8514  1278.3133   \n",
       "                                files\\S_01195   840.2082   994.3933   \n",
       "                                files\\S_01196   951.8634   575.5694   \n",
       "                                files\\S_01197   641.5186  1112.5620   \n",
       "                                files\\S_01198   615.3065   699.2889   \n",
       "                                files\\S_01199   504.6481  1625.7636   \n",
       "                                files\\S_01200   819.5741   763.5798   \n",
       "                                files\\S_01201   396.3134   871.4286   \n",
       "                                files\\S_01202   353.6068   636.4922   \n",
       "                                files\\S_01203   772.4235   718.2554   \n",
       "                                files\\S_01204   726.1291  1942.1311   \n",
       "                                files\\S_01205   714.9230  2165.0446   \n",
       "                                files\\S_01206   888.0615  2086.4761   \n",
       "                                files\\S_01207  1072.9974  1052.9716   \n",
       "                                files\\S_01208   746.8790  1028.8420   \n",
       "                                files\\S_01209   555.9026  2840.7245   \n",
       "                                files\\S_01210   894.9285  1288.6866   \n",
       "                                files\\S_01211   427.3377   592.9124   \n",
       "normal                          files\\S_01212   507.3746  1303.5398   \n",
       "tumoral                         files\\S_01213   513.4168   612.7013   \n",
       "                                files\\S_01214   402.9377   586.0633   \n",
       "                                files\\S_01215   546.6028   552.0810   \n",
       "                                files\\S_01216   658.7795  1375.1934   \n",
       "                                files\\S_01217   811.7104  1345.2634   \n",
       "\n",
       "                                                 ...                 \\\n",
       "gene_symbol                                      ...         ZWILCH   \n",
       "manually_curated__tissue_status sample           ...                  \n",
       "tumoral                         files\\S_00000    ...       197.4026   \n",
       "                                files\\S_00001    ...       569.2659   \n",
       "                                files\\S_00002    ...       188.4209   \n",
       "                                files\\S_00003    ...       609.5043   \n",
       "                                files\\S_00004    ...      1098.3573   \n",
       "                                files\\S_00005    ...       339.2024   \n",
       "                                files\\S_00006    ...       560.8543   \n",
       "                                files\\S_00007    ...       554.5112   \n",
       "                                files\\S_00008    ...       464.0932   \n",
       "                                files\\S_00009    ...       612.0480   \n",
       "                                files\\S_00010    ...       474.7652   \n",
       "                                files\\S_00011    ...       434.2048   \n",
       "                                files\\S_00012    ...       684.8686   \n",
       "                                files\\S_00013    ...       315.4778   \n",
       "                                files\\S_00014    ...       195.5303   \n",
       "normal                          files\\S_00015    ...       278.1186   \n",
       "tumoral                         files\\S_00016    ...       423.0551   \n",
       "                                files\\S_00017    ...       411.3501   \n",
       "                                files\\S_00018    ...       684.1710   \n",
       "                                files\\S_00019    ...       378.9784   \n",
       "                                files\\S_00020    ...       629.6931   \n",
       "normal                          files\\S_00021    ...       216.1701   \n",
       "tumoral                         files\\S_00022    ...       352.3834   \n",
       "                                files\\S_00023    ...       433.0986   \n",
       "normal                          files\\S_00024    ...       455.9685   \n",
       "tumoral                         files\\S_00025    ...       917.0162   \n",
       "                                files\\S_00026    ...      1259.4530   \n",
       "                                files\\S_00027    ...       453.9403   \n",
       "                                files\\S_00028    ...       386.7686   \n",
       "                                files\\S_00029    ...       334.0512   \n",
       "...                                              ...            ...   \n",
       "                                files\\S_01188    ...       307.0664   \n",
       "                                files\\S_01189    ...       430.3350   \n",
       "                                files\\S_01190    ...       417.2343   \n",
       "normal                          files\\S_01191    ...       194.3540   \n",
       "tumoral                         files\\S_01192    ...       679.1082   \n",
       "                                files\\S_01193    ...       348.2500   \n",
       "                                files\\S_01194    ...      1233.3012   \n",
       "                                files\\S_01195    ...      1094.6115   \n",
       "                                files\\S_01196    ...       306.9358   \n",
       "                                files\\S_01197    ...       486.2121   \n",
       "                                files\\S_01198    ...       337.2469   \n",
       "                                files\\S_01199    ...       352.8738   \n",
       "                                files\\S_01200    ...       594.9892   \n",
       "                                files\\S_01201    ...       289.2995   \n",
       "                                files\\S_01202    ...       799.9953   \n",
       "                                files\\S_01203    ...       745.5786   \n",
       "                                files\\S_01204    ...       235.6699   \n",
       "                                files\\S_01205    ...       336.3869   \n",
       "                                files\\S_01206    ...       289.3418   \n",
       "                                files\\S_01207    ...       253.6693   \n",
       "                                files\\S_01208    ...      1324.6061   \n",
       "                                files\\S_01209    ...      1043.4916   \n",
       "                                files\\S_01210    ...       778.3459   \n",
       "                                files\\S_01211    ...       475.8279   \n",
       "normal                          files\\S_01212    ...       208.8053   \n",
       "tumoral                         files\\S_01213    ...       528.0635   \n",
       "                                files\\S_01214    ...       551.4131   \n",
       "                                files\\S_01215    ...       462.7406   \n",
       "                                files\\S_01216    ...       496.5367   \n",
       "                                files\\S_01217    ...       283.8363   \n",
       "\n",
       "                                                                               \\\n",
       "gene_symbol                                        ZWINT      ZXDA       ZXDB   \n",
       "manually_curated__tissue_status sample                                          \n",
       "tumoral                         files\\S_00000   327.7922   64.6753  1089.6104   \n",
       "                                files\\S_00001   679.0375  147.6346   883.3605   \n",
       "                                files\\S_00002   567.5255   12.8700   168.5555   \n",
       "                                files\\S_00003   722.1312   43.7969   359.3413   \n",
       "                                files\\S_00004   291.0663  104.1581   792.9189   \n",
       "                                files\\S_00005  1364.7295   18.8377   206.4128   \n",
       "                                files\\S_00006   704.2745   40.7040   250.3772   \n",
       "                                files\\S_00007  1946.7275   63.5624   587.1703   \n",
       "                                files\\S_00008  1505.9322   53.3898   526.2712   \n",
       "                                files\\S_00009   599.8117   92.7495  1251.4124   \n",
       "                                files\\S_00010   321.2073   95.9568   519.4279   \n",
       "                                files\\S_00011   728.7495   68.0015   524.3672   \n",
       "                                files\\S_00012  1066.5069   76.0079   452.6235   \n",
       "                                files\\S_00013   347.6685   83.3624   625.6360   \n",
       "                                files\\S_00014   414.5162   19.7148   369.5260   \n",
       "normal                          files\\S_00015   153.8855   63.3947   494.3763   \n",
       "tumoral                         files\\S_00016   609.8807   57.3538   534.3555   \n",
       "                                files\\S_00017   335.5674   96.0828   561.6872   \n",
       "                                files\\S_00018  1164.0158   77.3018   540.1153   \n",
       "                                files\\S_00019   493.4656   86.5561  2508.5298   \n",
       "                                files\\S_00020  1674.2436   76.3979   687.9233   \n",
       "normal                          files\\S_00021   156.1856   75.7732   380.4124   \n",
       "tumoral                         files\\S_00022   916.5670  128.2895   889.9522   \n",
       "                                files\\S_00023   975.6098   95.3651   963.3754   \n",
       "normal                          files\\S_00024   301.0091  101.6490   698.4986   \n",
       "tumoral                         files\\S_00025  2811.9902   84.5209  1226.5356   \n",
       "                                files\\S_00026   803.5410  130.9726  1237.3170   \n",
       "                                files\\S_00027   620.4836   80.5121   623.8976   \n",
       "                                files\\S_00028   312.5162   89.1423   575.2786   \n",
       "                                files\\S_00029   669.7213   90.1107  1037.8007   \n",
       "...                                                  ...       ...        ...   \n",
       "                                files\\S_01188   575.7576  136.0413  1113.1528   \n",
       "                                files\\S_01189   319.6472   50.4043   328.4679   \n",
       "                                files\\S_01190  1169.5989   81.9845   830.4011   \n",
       "normal                          files\\S_01191   163.9994   90.6423   496.6357   \n",
       "tumoral                         files\\S_01192  1165.0465   81.9691   702.4634   \n",
       "                                files\\S_01193   563.6090   38.0378   502.8412   \n",
       "                                files\\S_01194  1849.3976   61.8474   877.5100   \n",
       "                                files\\S_01195  1755.5066   67.8815   681.2175   \n",
       "                                files\\S_01196   577.6398   60.0414   720.4969   \n",
       "                                files\\S_01197   965.7841   51.5053  1471.1643   \n",
       "                                files\\S_01198   264.4768   65.0186   601.7609   \n",
       "                                files\\S_01199   465.8699   51.2616   362.0186   \n",
       "                                files\\S_01200  1809.7631  155.5396  1938.0235   \n",
       "                                files\\S_01201  1144.7005   37.7880   252.5346   \n",
       "                                files\\S_01202   982.0839   52.8053   456.3885   \n",
       "                                files\\S_01203  2321.8431  138.9377  1128.7372   \n",
       "                                files\\S_01204  1034.0923   56.3593   673.0406   \n",
       "                                files\\S_01205   517.4371   58.7997   489.0511   \n",
       "                                files\\S_01206   770.1177   72.3036   580.5909   \n",
       "                                files\\S_01207   786.1757   10.9819   101.4212   \n",
       "                                files\\S_01208   456.7370   54.6707   517.8648   \n",
       "                                files\\S_01209  2266.0837   49.3442   540.9119   \n",
       "                                files\\S_01210  1576.5930   82.9649   664.2393   \n",
       "                                files\\S_01211   570.5777   38.7135   738.2370   \n",
       "normal                          files\\S_01212   110.9145   83.4808   461.6519   \n",
       "tumoral                         files\\S_01213   339.8927   80.5009   601.5206   \n",
       "                                files\\S_01214   756.6545   62.0610   733.1142   \n",
       "                                files\\S_01215   283.6491   87.0425   665.6015   \n",
       "                                files\\S_01216   604.6380   30.7384   451.9940   \n",
       "                                files\\S_01217   442.8914   60.5696   601.0669   \n",
       "\n",
       "                                                                               \\\n",
       "gene_symbol                                         ZXDC    ZYG11A     ZYG11B   \n",
       "manually_curated__tissue_status sample                                          \n",
       "tumoral                         files\\S_00000  1021.2987   15.3247   740.0000   \n",
       "                                files\\S_00001  1214.9266   74.6330   855.6281   \n",
       "                                files\\S_00002   520.6122   43.5919   473.2839   \n",
       "                                files\\S_00003   991.1199   67.5920   403.8279   \n",
       "                                files\\S_00004  1813.0918   63.8123  1041.1692   \n",
       "                                files\\S_00005   772.3447  133.8677   554.7094   \n",
       "                                files\\S_00006   557.0774   61.0561   533.4122   \n",
       "                                files\\S_00007  1303.5493  201.6281  1058.1570   \n",
       "                                files\\S_00008   752.5424   56.7797   596.6102   \n",
       "                                files\\S_00009  1072.9755  174.6704   911.0169   \n",
       "                                files\\S_00010  1415.9252   19.3716  1364.5681   \n",
       "                                files\\S_00011  1290.8954   61.9569   624.4805   \n",
       "                                files\\S_00012   805.2726   17.4613   878.5415   \n",
       "                                files\\S_00013  1054.7153  107.0607  1217.2580   \n",
       "                                files\\S_00014   926.5953   48.5287   339.7010   \n",
       "normal                          files\\S_00015  1085.3783   20.4499  1116.5644   \n",
       "tumoral                         files\\S_00016  1275.4117   44.8609   646.2237   \n",
       "                                files\\S_00017  1395.7294   50.5699  1116.1500   \n",
       "                                files\\S_00018  1191.9442  345.6139   838.3507   \n",
       "                                files\\S_00019   997.7906   12.7758   538.8197   \n",
       "                                files\\S_00020  1172.3474  178.8327  1260.0508   \n",
       "normal                          files\\S_00021  1036.5979    0.5155  1453.0928   \n",
       "tumoral                         files\\S_00022  1225.1794  330.1435   933.3134   \n",
       "                                files\\S_00023  1550.3098  210.4933  1081.9544   \n",
       "normal                          files\\S_00024  1199.3601  108.7866  1570.7605   \n",
       "tumoral                         files\\S_00025   937.9853  291.3022   873.9066   \n",
       "                                files\\S_00026  1506.5259   70.8206  1251.8443   \n",
       "                                files\\S_00027  1239.5448  193.1721  1040.1138   \n",
       "                                files\\S_00028  1146.1519  103.6538   868.3597   \n",
       "                                files\\S_00029  1076.3650  124.4750  1217.2585   \n",
       "...                                                  ...       ...        ...   \n",
       "                                files\\S_01188  2042.2308   27.4017  1385.2353   \n",
       "                                files\\S_01189  1004.7254   96.1882   546.4664   \n",
       "                                files\\S_01190  1260.3800  603.8001  2003.1668   \n",
       "normal                          files\\S_01191  1244.9620   27.8251   954.4849   \n",
       "tumoral                         files\\S_01192  1074.9407   40.0805  1094.8303   \n",
       "                                files\\S_01193   764.0032  150.7596   709.7298   \n",
       "                                files\\S_01194   959.0361   38.5542   839.7590   \n",
       "                                files\\S_01195  1225.2703  214.4573   662.3949   \n",
       "                                files\\S_01196  1129.9172   13.9752   679.0890   \n",
       "                                files\\S_01197  1595.4540   10.8814   954.1772   \n",
       "                                files\\S_01198  1771.4189   80.9346  1303.0816   \n",
       "                                files\\S_01199  1131.4741    2.6560   803.1873   \n",
       "                                files\\S_01200  1022.9720  190.4762   992.1034   \n",
       "                                files\\S_01201   732.7189  133.6406   800.9217   \n",
       "                                files\\S_01202  1214.0500  205.5634  1025.9312   \n",
       "                                files\\S_01203  1333.8023  159.6905   861.4140   \n",
       "                                files\\S_01204  1138.7596   57.8689  1028.3054   \n",
       "                                files\\S_01205   947.6886    5.6772   835.3609   \n",
       "                                files\\S_01206  1220.2738   19.9375  1097.5258   \n",
       "                                files\\S_01207  1323.6434   99.4832   475.4522   \n",
       "                                files\\S_01208  1085.6651   20.2325   910.0301   \n",
       "                                files\\S_01209   616.4897  131.7926   689.5690   \n",
       "                                files\\S_01210  1505.8518  110.0130   737.5813   \n",
       "                                files\\S_01211   765.6343  148.6004  1208.4574   \n",
       "normal                          files\\S_01212  1135.9882   17.6991  1331.5634   \n",
       "tumoral                         files\\S_01213  1011.6279   37.1199   823.7925   \n",
       "                                files\\S_01214   820.2441  188.0172  1443.2994   \n",
       "                                files\\S_01215  1275.2035   68.4775  1575.5916   \n",
       "                                files\\S_01216   906.7824   10.8283   608.4803   \n",
       "                                files\\S_01217  1128.0614   27.3914   927.4486   \n",
       "\n",
       "                                                                                \n",
       "gene_symbol                                          ZYX      ZZEF1       ZZZ3  \n",
       "manually_curated__tissue_status sample                                          \n",
       "tumoral                         files\\S_00000  1280.5195  1615.3247   842.5974  \n",
       "                                files\\S_00001  3809.1354  1853.5889   716.9657  \n",
       "                                files\\S_00002  4341.3414   807.9038   435.0890  \n",
       "                                files\\S_00003  6222.2605  1072.8511   442.7968  \n",
       "                                files\\S_00004  4456.1548  1162.6184   901.1939  \n",
       "                                files\\S_00005  2131.8637   347.8958   412.8257  \n",
       "                                files\\S_00006  6719.9527   627.1262   587.3687  \n",
       "                                files\\S_00007  2228.3295  1602.3445  1198.8277  \n",
       "                                files\\S_00008  4315.2542   394.0678   465.2542  \n",
       "                                files\\S_00009  6243.4087  1568.7382  1058.8512  \n",
       "                                files\\S_00010  6186.7327  1931.2986  1436.1978  \n",
       "                                files\\S_00011  3007.9335  1358.5191   994.7110  \n",
       "                                files\\S_00012  7295.3865  1105.8803  1054.8660  \n",
       "                                files\\S_00013  2124.7648  1948.8395  1556.8412  \n",
       "                                files\\S_00014  5440.2718   509.5516   255.7868  \n",
       "normal                          files\\S_00015  8266.8712  1337.9346  1019.4274  \n",
       "tumoral                         files\\S_00016  3204.9972   956.2748   593.4128  \n",
       "                                files\\S_00017  4323.0044  2009.7925  1151.9102  \n",
       "                                files\\S_00018  2721.5227  1247.8010  1093.1973  \n",
       "                                files\\S_00019  2842.2978   791.7807   655.0795  \n",
       "                                files\\S_00020  2124.7512  1417.9854  1018.5239  \n",
       "normal                          files\\S_00021  4177.3196  1769.5876   664.4330  \n",
       "tumoral                         files\\S_00022  2473.9833  1159.0909  1291.2679  \n",
       "                                files\\S_00023  1399.1060   822.5237  1145.0082  \n",
       "normal                          files\\S_00024  3515.6288  1821.5604  1427.5166  \n",
       "tumoral                         files\\S_00025  2914.9877   845.6020   793.7101  \n",
       "                                files\\S_00026  1570.7638  2434.2299   875.7235  \n",
       "                                files\\S_00027  2066.8563  1434.4239   902.9872  \n",
       "                                files\\S_00028  4629.1785  1646.7997  1048.1990  \n",
       "                                files\\S_00029  2527.3005   923.6350   767.0867  \n",
       "...                                                  ...        ...        ...  \n",
       "                                files\\S_01188  1067.3759  2440.0387  1277.2405  \n",
       "                                files\\S_01189  9633.5188  1265.9876   661.5562  \n",
       "                                files\\S_01190   876.1436   929.9789  1127.0232  \n",
       "normal                          files\\S_01191  8232.8538  1283.7485  1226.4119  \n",
       "tumoral                         files\\S_01192  1557.1121  1870.8248   854.6487  \n",
       "                                files\\S_01193  3551.4322   608.1410   841.0066  \n",
       "                                files\\S_01194  5763.0522  1112.4498   630.5221  \n",
       "                                files\\S_01195  2621.7461   915.6988   721.8662  \n",
       "                                files\\S_01196  4408.9027  1293.9959   952.8986  \n",
       "                                files\\S_01197  2799.6615  1084.9958  1121.2671  \n",
       "                                files\\S_01198  2557.3993  1781.2394  1158.8215  \n",
       "                                files\\S_01199  6243.5591  1193.3599   538.9110  \n",
       "                                files\\S_01200  1865.5181  1347.4515  1465.9009  \n",
       "                                files\\S_01201  8333.6406   810.1382   835.4839  \n",
       "                                files\\S_01202  4735.9736   806.6950   727.4870  \n",
       "                                files\\S_01203  2645.4450   272.9511   521.2803  \n",
       "                                files\\S_01204  3036.6084  1091.9613  1030.0667  \n",
       "                                files\\S_01205  3729.9270  1327.2506   761.9627  \n",
       "                                files\\S_01206  1017.7756  2648.5707  1828.2489  \n",
       "                                files\\S_01207  4866.9251   579.4574   536.8217  \n",
       "                                files\\S_01208  3315.5402   557.0383  1085.2346  \n",
       "                                files\\S_01209  2394.7533  1180.5122   823.8601  \n",
       "                                files\\S_01210  2076.4629  1600.7802   867.6203  \n",
       "                                files\\S_01211  4396.6647   288.5646   671.8285  \n",
       "normal                          files\\S_01212  4989.6755  1836.8732   998.8201  \n",
       "tumoral                         files\\S_01213  4295.1699  1004.0250   913.2379  \n",
       "                                files\\S_01214  2548.1679   706.8223  1868.2489  \n",
       "                                files\\S_01215  2623.4497   838.1648  2056.7603  \n",
       "                                files\\S_01216  3680.2230   960.5745   780.6851  \n",
       "                                files\\S_01217  2272.3261  1197.5043   641.5753  \n",
       "\n",
       "[1218 rows x 20207 columns]"
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "regiondata"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Get labels from the index"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "1218"
      ]
     },
     "execution_count": 4,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "lbls = regiondata.index.get_level_values('manually_curated__tissue_status')\n",
    "len(lbls)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "lbls= [\"1\" if x==\"tumoral\" else \"0\" for x in lbls]\n",
    "for i in range(len(lbls)):\n",
    "    lbls[i] = int(lbls[i])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Dump the unnecessery columns"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
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       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th>gene_symbol</th>\n",
       "      <th>A1BG</th>\n",
       "      <th>A1BG-AS1</th>\n",
       "      <th>A1CF</th>\n",
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       "      <th>ZYX</th>\n",
       "      <th>ZZEF1</th>\n",
       "      <th>ZZZ3</th>\n",
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       "    <tr>\n",
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       "      <td>104.4156</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>825.9740</td>\n",
       "      <td>741.5584</td>\n",
       "      <td>...</td>\n",
       "      <td>197.4026</td>\n",
       "      <td>327.7922</td>\n",
       "      <td>64.6753</td>\n",
       "      <td>1089.6104</td>\n",
       "      <td>1021.2987</td>\n",
       "      <td>15.3247</td>\n",
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       "      <td>1280.5195</td>\n",
       "      <td>1615.3247</td>\n",
       "      <td>842.5974</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00001</th>\n",
       "      <td>128.9070</td>\n",
       "      <td>183.4258</td>\n",
       "      <td>0.4078</td>\n",
       "      <td>14028.9356</td>\n",
       "      <td>15.5179</td>\n",
       "      <td>3.6705</td>\n",
       "      <td>183.9315</td>\n",
       "      <td>1.6313</td>\n",
       "      <td>676.9984</td>\n",
       "      <td>855.6281</td>\n",
       "      <td>...</td>\n",
       "      <td>569.2659</td>\n",
       "      <td>679.0375</td>\n",
       "      <td>147.6346</td>\n",
       "      <td>883.3605</td>\n",
       "      <td>1214.9266</td>\n",
       "      <td>74.6330</td>\n",
       "      <td>855.6281</td>\n",
       "      <td>3809.1354</td>\n",
       "      <td>1853.5889</td>\n",
       "      <td>716.9657</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00002</th>\n",
       "      <td>161.2486</td>\n",
       "      <td>100.7430</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>17754.2889</td>\n",
       "      <td>23.3321</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>807.9038</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>668.4097</td>\n",
       "      <td>919.9974</td>\n",
       "      <td>...</td>\n",
       "      <td>188.4209</td>\n",
       "      <td>567.5255</td>\n",
       "      <td>12.8700</td>\n",
       "      <td>168.5555</td>\n",
       "      <td>520.6122</td>\n",
       "      <td>43.5919</td>\n",
       "      <td>473.2839</td>\n",
       "      <td>4341.3414</td>\n",
       "      <td>807.9038</td>\n",
       "      <td>435.0890</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00003</th>\n",
       "      <td>127.1454</td>\n",
       "      <td>127.8283</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>9604.5625</td>\n",
       "      <td>22.4744</td>\n",
       "      <td>7.2420</td>\n",
       "      <td>209.3284</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>919.3896</td>\n",
       "      <td>781.1018</td>\n",
       "      <td>...</td>\n",
       "      <td>609.5043</td>\n",
       "      <td>722.1312</td>\n",
       "      <td>43.7969</td>\n",
       "      <td>359.3413</td>\n",
       "      <td>991.1199</td>\n",
       "      <td>67.5920</td>\n",
       "      <td>403.8279</td>\n",
       "      <td>6222.2605</td>\n",
       "      <td>1072.8511</td>\n",
       "      <td>442.7968</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00004</th>\n",
       "      <td>74.5163</td>\n",
       "      <td>141.5685</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>11410.8522</td>\n",
       "      <td>25.1297</td>\n",
       "      <td>25.1132</td>\n",
       "      <td>274.1869</td>\n",
       "      <td>4.5286</td>\n",
       "      <td>669.4113</td>\n",
       "      <td>1374.6398</td>\n",
       "      <td>...</td>\n",
       "      <td>1098.3573</td>\n",
       "      <td>291.0663</td>\n",
       "      <td>104.1581</td>\n",
       "      <td>792.9189</td>\n",
       "      <td>1813.0918</td>\n",
       "      <td>63.8123</td>\n",
       "      <td>1041.1692</td>\n",
       "      <td>4456.1548</td>\n",
       "      <td>1162.6184</td>\n",
       "      <td>901.1939</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>5 rows × 20207 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "gene_symbol        A1BG  A1BG-AS1    A1CF         A2M  A2M-AS1    A2ML1  \\\n",
       "sample                                                                    \n",
       "files\\S_00000  216.9506  214.4831  0.0000   4648.3610  28.5221   1.0390   \n",
       "files\\S_00001  128.9070  183.4258  0.4078  14028.9356  15.5179   3.6705   \n",
       "files\\S_00002  161.2486  100.7430  0.0000  17754.2889  23.3321   0.0000   \n",
       "files\\S_00003  127.1454  127.8283  0.0000   9604.5625  22.4744   7.2420   \n",
       "files\\S_00004   74.5163  141.5685  0.0000  11410.8522  25.1297  25.1132   \n",
       "\n",
       "gene_symbol      A4GALT   A4GNT      AAAS       AACS    ...        ZWILCH  \\\n",
       "sample                                                  ...                 \n",
       "files\\S_00000  104.4156  0.0000  825.9740   741.5584    ...      197.4026   \n",
       "files\\S_00001  183.9315  1.6313  676.9984   855.6281    ...      569.2659   \n",
       "files\\S_00002  807.9038  0.0000  668.4097   919.9974    ...      188.4209   \n",
       "files\\S_00003  209.3284  0.0000  919.3896   781.1018    ...      609.5043   \n",
       "files\\S_00004  274.1869  4.5286  669.4113  1374.6398    ...     1098.3573   \n",
       "\n",
       "gene_symbol       ZWINT      ZXDA       ZXDB       ZXDC   ZYG11A     ZYG11B  \\\n",
       "sample                                                                        \n",
       "files\\S_00000  327.7922   64.6753  1089.6104  1021.2987  15.3247   740.0000   \n",
       "files\\S_00001  679.0375  147.6346   883.3605  1214.9266  74.6330   855.6281   \n",
       "files\\S_00002  567.5255   12.8700   168.5555   520.6122  43.5919   473.2839   \n",
       "files\\S_00003  722.1312   43.7969   359.3413   991.1199  67.5920   403.8279   \n",
       "files\\S_00004  291.0663  104.1581   792.9189  1813.0918  63.8123  1041.1692   \n",
       "\n",
       "gene_symbol          ZYX      ZZEF1      ZZZ3  \n",
       "sample                                         \n",
       "files\\S_00000  1280.5195  1615.3247  842.5974  \n",
       "files\\S_00001  3809.1354  1853.5889  716.9657  \n",
       "files\\S_00002  4341.3414   807.9038  435.0890  \n",
       "files\\S_00003  6222.2605  1072.8511  442.7968  \n",
       "files\\S_00004  4456.1548  1162.6184  901.1939  \n",
       "\n",
       "[5 rows x 20207 columns]"
      ]
     },
     "execution_count": 6,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "regiondata = regiondata.normalized_count\n",
    "regiondata.index = regiondata.index.get_level_values(-1)\n",
    "regiondata.head()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {
    "collapsed": true,
    "scrolled": true
   },
   "outputs": [],
   "source": [
    "regiondata = regiondata.fillna(regiondata.mean())\n",
    "regiondata = regiondata.dropna(axis=1, how='all')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
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       "      <td>1615.3247</td>\n",
       "      <td>842.5974</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00001</th>\n",
       "      <td>128.9070</td>\n",
       "      <td>183.4258</td>\n",
       "      <td>0.4078</td>\n",
       "      <td>14028.9356</td>\n",
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       "      <td>569.2659</td>\n",
       "      <td>679.0375</td>\n",
       "      <td>147.6346</td>\n",
       "      <td>883.3605</td>\n",
       "      <td>1214.9266</td>\n",
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       "      <td>3809.1354</td>\n",
       "      <td>1853.5889</td>\n",
       "      <td>716.9657</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_00002</th>\n",
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       "      <td>100.7430</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>17754.2889</td>\n",
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       "      <td>0.0000</td>\n",
       "      <td>807.9038</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>668.4097</td>\n",
       "      <td>919.9974</td>\n",
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       "      <td>188.4209</td>\n",
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       "      <td>168.5555</td>\n",
       "      <td>520.6122</td>\n",
       "      <td>43.5919</td>\n",
       "      <td>473.2839</td>\n",
       "      <td>4341.3414</td>\n",
       "      <td>807.9038</td>\n",
       "      <td>435.0890</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00003</th>\n",
       "      <td>127.1454</td>\n",
       "      <td>127.8283</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>9604.5625</td>\n",
       "      <td>22.4744</td>\n",
       "      <td>7.2420</td>\n",
       "      <td>209.3284</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>919.3896</td>\n",
       "      <td>781.1018</td>\n",
       "      <td>...</td>\n",
       "      <td>609.5043</td>\n",
       "      <td>722.1312</td>\n",
       "      <td>43.7969</td>\n",
       "      <td>359.3413</td>\n",
       "      <td>991.1199</td>\n",
       "      <td>67.5920</td>\n",
       "      <td>403.8279</td>\n",
       "      <td>6222.2605</td>\n",
       "      <td>1072.8511</td>\n",
       "      <td>442.7968</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00004</th>\n",
       "      <td>74.5163</td>\n",
       "      <td>141.5685</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>11410.8522</td>\n",
       "      <td>25.1297</td>\n",
       "      <td>25.1132</td>\n",
       "      <td>274.1869</td>\n",
       "      <td>4.5286</td>\n",
       "      <td>669.4113</td>\n",
       "      <td>1374.6398</td>\n",
       "      <td>...</td>\n",
       "      <td>1098.3573</td>\n",
       "      <td>291.0663</td>\n",
       "      <td>104.1581</td>\n",
       "      <td>792.9189</td>\n",
       "      <td>1813.0918</td>\n",
       "      <td>63.8123</td>\n",
       "      <td>1041.1692</td>\n",
       "      <td>4456.1548</td>\n",
       "      <td>1162.6184</td>\n",
       "      <td>901.1939</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00005</th>\n",
       "      <td>341.4830</td>\n",
       "      <td>155.5912</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>2512.5972</td>\n",
       "      <td>13.2545</td>\n",
       "      <td>0.8016</td>\n",
       "      <td>521.0421</td>\n",
       "      <td>0.4008</td>\n",
       "      <td>1204.8096</td>\n",
       "      <td>1553.1062</td>\n",
       "      <td>...</td>\n",
       "      <td>339.2024</td>\n",
       "      <td>1364.7295</td>\n",
       "      <td>18.8377</td>\n",
       "      <td>206.4128</td>\n",
       "      <td>772.3447</td>\n",
       "      <td>133.8677</td>\n",
       "      <td>554.7094</td>\n",
       "      <td>2131.8637</td>\n",
       "      <td>347.8958</td>\n",
       "      <td>412.8257</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_00006</th>\n",
       "      <td>180.3284</td>\n",
       "      <td>109.5081</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>28739.2847</td>\n",
       "      <td>55.5089</td>\n",
       "      <td>3515.2196</td>\n",
       "      <td>2097.6779</td>\n",
       "      <td>0.9466</td>\n",
       "      <td>566.0701</td>\n",
       "      <td>1144.9194</td>\n",
       "      <td>...</td>\n",
       "      <td>560.8543</td>\n",
       "      <td>704.2745</td>\n",
       "      <td>40.7040</td>\n",
       "      <td>250.3772</td>\n",
       "      <td>557.0774</td>\n",
       "      <td>61.0561</td>\n",
       "      <td>533.4122</td>\n",
       "      <td>6719.9527</td>\n",
       "      <td>627.1262</td>\n",
       "      <td>587.3687</td>\n",
       "    </tr>\n",
       "    <tr>\n",
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       "      <td>0.8110</td>\n",
       "      <td>779.3998</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>714.9230</td>\n",
       "      <td>2165.0446</td>\n",
       "      <td>...</td>\n",
       "      <td>336.3869</td>\n",
       "      <td>517.4371</td>\n",
       "      <td>58.7997</td>\n",
       "      <td>489.0511</td>\n",
       "      <td>947.6886</td>\n",
       "      <td>5.6772</td>\n",
       "      <td>835.3609</td>\n",
       "      <td>3729.9270</td>\n",
       "      <td>1327.2506</td>\n",
       "      <td>761.9627</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01206</th>\n",
       "      <td>151.3668</td>\n",
       "      <td>225.8155</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>2269.1737</td>\n",
       "      <td>21.4821</td>\n",
       "      <td>0.4804</td>\n",
       "      <td>54.2878</td>\n",
       "      <td>0.2402</td>\n",
       "      <td>888.0615</td>\n",
       "      <td>2086.4761</td>\n",
       "      <td>...</td>\n",
       "      <td>289.3418</td>\n",
       "      <td>770.1177</td>\n",
       "      <td>72.3036</td>\n",
       "      <td>580.5909</td>\n",
       "      <td>1220.2738</td>\n",
       "      <td>19.9375</td>\n",
       "      <td>1097.5258</td>\n",
       "      <td>1017.7756</td>\n",
       "      <td>2648.5707</td>\n",
       "      <td>1828.2489</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>files\\S_01207</th>\n",
       "      <td>563.9018</td>\n",
       "      <td>180.9173</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>4369.9548</td>\n",
       "      <td>24.1021</td>\n",
       "      <td>427.6486</td>\n",
       "      <td>483.8501</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>1072.9974</td>\n",
       "      <td>1052.9716</td>\n",
       "      <td>...</td>\n",
       "      <td>253.6693</td>\n",
       "      <td>786.1757</td>\n",
       "      <td>10.9819</td>\n",
       "      <td>101.4212</td>\n",
       "      <td>1323.6434</td>\n",
       "      <td>99.4832</td>\n",
       "      <td>475.4522</td>\n",
       "      <td>4866.9251</td>\n",
       "      <td>579.4574</td>\n",
       "      <td>536.8217</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01208</th>\n",
       "      <td>159.2768</td>\n",
       "      <td>98.3943</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>21885.9105</td>\n",
       "      <td>16.8015</td>\n",
       "      <td>3.0133</td>\n",
       "      <td>128.7129</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>746.8790</td>\n",
       "      <td>1028.8420</td>\n",
       "      <td>...</td>\n",
       "      <td>1324.6061</td>\n",
       "      <td>456.7370</td>\n",
       "      <td>54.6707</td>\n",
       "      <td>517.8648</td>\n",
       "      <td>1085.6651</td>\n",
       "      <td>20.2325</td>\n",
       "      <td>910.0301</td>\n",
       "      <td>3315.5402</td>\n",
       "      <td>557.0383</td>\n",
       "      <td>1085.2346</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01209</th>\n",
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       "      <td>8626.3960</td>\n",
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       "      <td>0.0000</td>\n",
       "      <td>555.9026</td>\n",
       "      <td>2840.7245</td>\n",
       "      <td>...</td>\n",
       "      <td>1043.4916</td>\n",
       "      <td>2266.0837</td>\n",
       "      <td>49.3442</td>\n",
       "      <td>540.9119</td>\n",
       "      <td>616.4897</td>\n",
       "      <td>131.7926</td>\n",
       "      <td>689.5690</td>\n",
       "      <td>2394.7533</td>\n",
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       "      <td>823.8601</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01210</th>\n",
       "      <td>191.3550</td>\n",
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       "      <td>7952.8999</td>\n",
       "      <td>8.3485</td>\n",
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       "      <td>233.2900</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>894.9285</td>\n",
       "      <td>1288.6866</td>\n",
       "      <td>...</td>\n",
       "      <td>778.3459</td>\n",
       "      <td>1576.5930</td>\n",
       "      <td>82.9649</td>\n",
       "      <td>664.2393</td>\n",
       "      <td>1505.8518</td>\n",
       "      <td>110.0130</td>\n",
       "      <td>737.5813</td>\n",
       "      <td>2076.4629</td>\n",
       "      <td>1600.7802</td>\n",
       "      <td>867.6203</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01211</th>\n",
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       "      <td>4794.4997</td>\n",
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       "      <td>522.0369</td>\n",
       "      <td>0.5956</td>\n",
       "      <td>427.3377</td>\n",
       "      <td>592.9124</td>\n",
       "      <td>...</td>\n",
       "      <td>475.8279</td>\n",
       "      <td>570.5777</td>\n",
       "      <td>38.7135</td>\n",
       "      <td>738.2370</td>\n",
       "      <td>765.6343</td>\n",
       "      <td>148.6004</td>\n",
       "      <td>1208.4574</td>\n",
       "      <td>4396.6647</td>\n",
       "      <td>288.5646</td>\n",
       "      <td>671.8285</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01212</th>\n",
       "      <td>33.0383</td>\n",
       "      <td>99.5723</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>53114.9853</td>\n",
       "      <td>59.9410</td>\n",
       "      <td>5.0147</td>\n",
       "      <td>723.8938</td>\n",
       "      <td>1.4749</td>\n",
       "      <td>507.3746</td>\n",
       "      <td>1303.5398</td>\n",
       "      <td>...</td>\n",
       "      <td>208.8053</td>\n",
       "      <td>110.9145</td>\n",
       "      <td>83.4808</td>\n",
       "      <td>461.6519</td>\n",
       "      <td>1135.9882</td>\n",
       "      <td>17.6991</td>\n",
       "      <td>1331.5634</td>\n",
       "      <td>4989.6755</td>\n",
       "      <td>1836.8732</td>\n",
       "      <td>998.8201</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01213</th>\n",
       "      <td>205.5411</td>\n",
       "      <td>180.5188</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>15451.6458</td>\n",
       "      <td>28.2290</td>\n",
       "      <td>1.3417</td>\n",
       "      <td>659.6601</td>\n",
       "      <td>0.0000</td>\n",
       "      <td>513.4168</td>\n",
       "      <td>612.7013</td>\n",
       "      <td>...</td>\n",
       "      <td>528.0635</td>\n",
       "      <td>339.8927</td>\n",
       "      <td>80.5009</td>\n",
       "      <td>601.5206</td>\n",
       "      <td>1011.6279</td>\n",
       "      <td>37.1199</td>\n",
       "      <td>823.7925</td>\n",
       "      <td>4295.1699</td>\n",
       "      <td>1004.0250</td>\n",
       "      <td>913.2379</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01214</th>\n",
       "      <td>30.8776</td>\n",
       "      <td>62.1985</td>\n",
       "      <td>0.3057</td>\n",
       "      <td>12046.1697</td>\n",
       "      <td>41.0428</td>\n",
       "      <td>450.9355</td>\n",
       "      <td>121.3704</td>\n",
       "      <td>0.3057</td>\n",
       "      <td>402.9377</td>\n",
       "      <td>586.0633</td>\n",
       "      <td>...</td>\n",
       "      <td>551.4131</td>\n",
       "      <td>756.6545</td>\n",
       "      <td>62.0610</td>\n",
       "      <td>733.1142</td>\n",
       "      <td>820.2441</td>\n",
       "      <td>188.0172</td>\n",
       "      <td>1443.2994</td>\n",
       "      <td>2548.1679</td>\n",
       "      <td>706.8223</td>\n",
       "      <td>1868.2489</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01215</th>\n",
       "      <td>115.6844</td>\n",
       "      <td>127.5295</td>\n",
       "      <td>0.3043</td>\n",
       "      <td>13477.5044</td>\n",
       "      <td>66.4354</td>\n",
       "      <td>0.6087</td>\n",
       "      <td>62.3906</td>\n",
       "      <td>0.3043</td>\n",
       "      <td>546.6028</td>\n",
       "      <td>552.0810</td>\n",
       "      <td>...</td>\n",
       "      <td>462.7406</td>\n",
       "      <td>283.6491</td>\n",
       "      <td>87.0425</td>\n",
       "      <td>665.6015</td>\n",
       "      <td>1275.2035</td>\n",
       "      <td>68.4775</td>\n",
       "      <td>1575.5916</td>\n",
       "      <td>2623.4497</td>\n",
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       "      <td>2056.7603</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01216</th>\n",
       "      <td>270.0507</td>\n",
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       "      <td>25304.6523</td>\n",
       "      <td>33.9065</td>\n",
       "      <td>10.1297</td>\n",
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       "      <td>0.3493</td>\n",
       "      <td>658.7795</td>\n",
       "      <td>1375.1934</td>\n",
       "      <td>...</td>\n",
       "      <td>496.5367</td>\n",
       "      <td>604.6380</td>\n",
       "      <td>30.7384</td>\n",
       "      <td>451.9940</td>\n",
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       "      <td>608.4803</td>\n",
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       "      <td>780.6851</td>\n",
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       "    <tr>\n",
       "      <th>files\\S_01217</th>\n",
       "      <td>315.0663</td>\n",
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       "      <td>5901.0304</td>\n",
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       "      <td>283.8363</td>\n",
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       "      <td>60.5696</td>\n",
       "      <td>601.0669</td>\n",
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       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>1218 rows × 20207 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "gene_symbol        A1BG  A1BG-AS1    A1CF         A2M   A2M-AS1      A2ML1  \\\n",
       "sample                                                                       \n",
       "files\\S_00000  216.9506  214.4831  0.0000   4648.3610   28.5221     1.0390   \n",
       "files\\S_00001  128.9070  183.4258  0.4078  14028.9356   15.5179     3.6705   \n",
       "files\\S_00002  161.2486  100.7430  0.0000  17754.2889   23.3321     0.0000   \n",
       "files\\S_00003  127.1454  127.8283  0.0000   9604.5625   22.4744     7.2420   \n",
       "files\\S_00004   74.5163  141.5685  0.0000  11410.8522   25.1297    25.1132   \n",
       "files\\S_00005  341.4830  155.5912  0.0000   2512.5972   13.2545     0.8016   \n",
       "files\\S_00006  180.3284  109.5081  0.0000  28739.2847   55.5089  3515.2196   \n",
       "files\\S_00007  101.3246  120.9196  0.0000   8586.3106   24.0443     0.5210   \n",
       "files\\S_00008  117.7966   73.5508  0.0000   9871.0847   11.9661     5.0847   \n",
       "files\\S_00009  192.7825  251.1441  0.0000   9226.3842   15.1412     0.4708   \n",
       "files\\S_00010   49.1992   75.0039  0.0000  31626.9490   28.4176     3.1535   \n",
       "files\\S_00011  222.6672  175.3532  0.0000  10548.8553   36.7133     1.8889   \n",
       "files\\S_00012  220.4913  269.9923  0.0000  28120.3800   36.4290  2312.7621   \n",
       "files\\S_00013  100.5562  130.1150  0.0000   8568.4645   18.1390     0.8364   \n",
       "files\\S_00014  616.6585  180.1730  0.0000   7832.7832   16.7374     0.5055   \n",
       "files\\S_00015   80.8742  128.5481  0.0000  25382.8067   68.6247    48.0573   \n",
       "files\\S_00016  142.8677   88.0352  0.0000   8592.7825   26.1840    27.2572   \n",
       "files\\S_00017  111.3007  126.4392  0.0000  29446.7761   39.4517    27.8134   \n",
       "files\\S_00018  498.7862  250.2883  0.0000   6228.5266   19.4551     6.4834   \n",
       "files\\S_00019   78.1975  129.2912  0.0000  17460.6102   49.9119     2.2358   \n",
       "files\\S_00020   77.9087  106.2513  0.0000   9805.9392   13.4124     0.3426   \n",
       "files\\S_00021   19.0722   33.5206  0.0000  41867.0567   72.6340     9.7938   \n",
       "files\\S_00022  106.6447  131.5072  0.0000   6882.3774   29.1059    48.4450   \n",
       "files\\S_00023  104.6192  134.1636  0.0000   5761.7285   27.3077     0.6274   \n",
       "files\\S_00024   49.2346  105.1292  0.0000  33165.7199   88.5257   105.5870   \n",
       "files\\S_00025  408.9985  317.6138  0.0000   4542.8757   14.1759     3.5381   \n",
       "files\\S_00026   28.4304   67.3590  0.0000  11944.5988   92.6274     2.0429   \n",
       "files\\S_00027  134.9986  156.4523  0.0000   7612.7283   27.9545     6.5434   \n",
       "files\\S_00028  189.4169  139.7979  0.0000  15693.0656   29.1423     5.4418   \n",
       "files\\S_00029  104.2612  112.4857  0.0000  34667.9763   53.2913     3.0546   \n",
       "...                 ...       ...     ...         ...       ...        ...   \n",
       "files\\S_01188  101.1541  134.2876  0.0000  10181.7311  203.8266     0.0000   \n",
       "files\\S_01189  198.8155  134.2182  0.0000  17129.4172   27.7812     5.0404   \n",
       "files\\S_01190   36.3125   63.4694  0.3519   7903.5749   11.2738    56.6502   \n",
       "files\\S_01191  103.0203  149.4418  0.0000  26732.5545   42.7705    53.9638   \n",
       "files\\S_01192   67.4286  149.3827  0.0000   8850.8124   18.1266     0.0000   \n",
       "files\\S_01193  205.0052  230.4302  0.0000  16641.0205   34.8463     0.0000   \n",
       "files\\S_01194  231.0080  131.8916  0.0000  13194.3494   16.4940     0.0000   \n",
       "files\\S_01195   74.6616  102.5811  0.0000   6185.1982   12.6392     1.6019   \n",
       "files\\S_01196  462.6501  347.1687  0.5176  14337.4379   11.4234     0.0000   \n",
       "files\\S_01197  130.9902  153.8508  0.0000   7032.0082   15.2654     0.2418   \n",
       "files\\S_01198   96.4748  135.7230  0.0000   4946.4883    6.4409     0.3386   \n",
       "files\\S_01199  139.5113  180.9456  0.0000  19459.9708   18.1169     1.5936   \n",
       "files\\S_01200  124.5250   82.1632  0.0000   5481.4429   10.3015     0.0000   \n",
       "files\\S_01201   35.0230   40.6498  0.0000  16361.7097   23.0829   384.7926   \n",
       "files\\S_01202  137.2796  191.7680  0.0000  15847.2183   16.0537  3037.2466   \n",
       "files\\S_01203   85.1178  151.8677  0.0000   8260.9638   22.1878     1.7587   \n",
       "files\\S_01204  112.2456  240.4453  0.2516   8443.0218   18.6715     1.0064   \n",
       "files\\S_01205  199.4404  123.4023  0.0000   6768.3049   29.7486     0.8110   \n",
       "files\\S_01206  151.3668  225.8155  0.0000   2269.1737   21.4821     0.4804   \n",
       "files\\S_01207  563.9018  180.9173  0.0000   4369.9548   24.1021   427.6486   \n",
       "files\\S_01208  159.2768   98.3943  0.0000  21885.9105   16.8015     3.0133   \n",
       "files\\S_01209   62.4047   38.9944  0.0000   8626.3960   21.9488    40.5996   \n",
       "files\\S_01210  191.3550  137.4746  0.0000   7952.8999    8.3485    86.0858   \n",
       "files\\S_01211   83.0554  140.0506  0.0000   4794.4997   14.9107     0.5956   \n",
       "files\\S_01212   33.0383   99.5723  0.0000  53114.9853   59.9410     5.0147   \n",
       "files\\S_01213  205.5411  180.5188  0.0000  15451.6458   28.2290     1.3417   \n",
       "files\\S_01214   30.8776   62.1985  0.3057  12046.1697   41.0428   450.9355   \n",
       "files\\S_01215  115.6844  127.5295  0.3043  13477.5044   66.4354     0.6087   \n",
       "files\\S_01216  270.0507  218.2355  0.0000  25304.6523   33.9065    10.1297   \n",
       "files\\S_01217  315.0663  290.0399  0.0000   5901.0304   27.4647     8.8733   \n",
       "\n",
       "gene_symbol       A4GALT   A4GNT       AAAS       AACS    ...         ZWILCH  \\\n",
       "sample                                                    ...                  \n",
       "files\\S_00000   104.4156  0.0000   825.9740   741.5584    ...       197.4026   \n",
       "files\\S_00001   183.9315  1.6313   676.9984   855.6281    ...       569.2659   \n",
       "files\\S_00002   807.9038  0.0000   668.4097   919.9974    ...       188.4209   \n",
       "files\\S_00003   209.3284  0.0000   919.3896   781.1018    ...       609.5043   \n",
       "files\\S_00004   274.1869  4.5286   669.4113  1374.6398    ...      1098.3573   \n",
       "files\\S_00005   521.0421  0.4008  1204.8096  1553.1062    ...       339.2024   \n",
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       "sample                                                                          \n",
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       "files\\S_01217   442.8914   60.5696   601.0669  1128.0614   27.3914   927.4486   \n",
       "\n",
       "gene_symbol          ZYX      ZZEF1       ZZZ3  \n",
       "sample                                          \n",
       "files\\S_00000  1280.5195  1615.3247   842.5974  \n",
       "files\\S_00001  3809.1354  1853.5889   716.9657  \n",
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       "files\\S_00004  4456.1548  1162.6184   901.1939  \n",
       "files\\S_00005  2131.8637   347.8958   412.8257  \n",
       "files\\S_00006  6719.9527   627.1262   587.3687  \n",
       "files\\S_00007  2228.3295  1602.3445  1198.8277  \n",
       "files\\S_00008  4315.2542   394.0678   465.2542  \n",
       "files\\S_00009  6243.4087  1568.7382  1058.8512  \n",
       "files\\S_00010  6186.7327  1931.2986  1436.1978  \n",
       "files\\S_00011  3007.9335  1358.5191   994.7110  \n",
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       "files\\S_00029  2527.3005   923.6350   767.0867  \n",
       "...                  ...        ...        ...  \n",
       "files\\S_01188  1067.3759  2440.0387  1277.2405  \n",
       "files\\S_01189  9633.5188  1265.9876   661.5562  \n",
       "files\\S_01190   876.1436   929.9789  1127.0232  \n",
       "files\\S_01191  8232.8538  1283.7485  1226.4119  \n",
       "files\\S_01192  1557.1121  1870.8248   854.6487  \n",
       "files\\S_01193  3551.4322   608.1410   841.0066  \n",
       "files\\S_01194  5763.0522  1112.4498   630.5221  \n",
       "files\\S_01195  2621.7461   915.6988   721.8662  \n",
       "files\\S_01196  4408.9027  1293.9959   952.8986  \n",
       "files\\S_01197  2799.6615  1084.9958  1121.2671  \n",
       "files\\S_01198  2557.3993  1781.2394  1158.8215  \n",
       "files\\S_01199  6243.5591  1193.3599   538.9110  \n",
       "files\\S_01200  1865.5181  1347.4515  1465.9009  \n",
       "files\\S_01201  8333.6406   810.1382   835.4839  \n",
       "files\\S_01202  4735.9736   806.6950   727.4870  \n",
       "files\\S_01203  2645.4450   272.9511   521.2803  \n",
       "files\\S_01204  3036.6084  1091.9613  1030.0667  \n",
       "files\\S_01205  3729.9270  1327.2506   761.9627  \n",
       "files\\S_01206  1017.7756  2648.5707  1828.2489  \n",
       "files\\S_01207  4866.9251   579.4574   536.8217  \n",
       "files\\S_01208  3315.5402   557.0383  1085.2346  \n",
       "files\\S_01209  2394.7533  1180.5122   823.8601  \n",
       "files\\S_01210  2076.4629  1600.7802   867.6203  \n",
       "files\\S_01211  4396.6647   288.5646   671.8285  \n",
       "files\\S_01212  4989.6755  1836.8732   998.8201  \n",
       "files\\S_01213  4295.1699  1004.0250   913.2379  \n",
       "files\\S_01214  2548.1679   706.8223  1868.2489  \n",
       "files\\S_01215  2623.4497   838.1648  2056.7603  \n",
       "files\\S_01216  3680.2230   960.5745   780.6851  \n",
       "files\\S_01217  2272.3261  1197.5043   641.5753  \n",
       "\n",
       "[1218 rows x 20207 columns]"
      ]
     },
     "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "regiondata"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th>gene_symbol</th>\n",
       "      <th>A1BG</th>\n",
       "      <th>A1BG-AS1</th>\n",
       "      <th>A1CF</th>\n",
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       "      <th>files\\S_00000</th>\n",
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       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>1218 rows × 20207 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "gene_symbol        A1BG  A1BG-AS1      A1CF       A2M   A2M-AS1     A2ML1  \\\n",
       "sample                                                                      \n",
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       "files\\S_00001 -0.007647  0.040938  0.001374 -0.010241 -0.080249 -0.012674   \n",
       "files\\S_00002 -0.003477 -0.054414 -0.001919  0.004855 -0.044890 -0.012859   \n",
       "files\\S_00003 -0.007874 -0.023178 -0.001919 -0.028169 -0.048771 -0.012493   \n",
       "files\\S_00004 -0.014659 -0.007333 -0.001919 -0.020849 -0.036756 -0.011589   \n",
       "files\\S_00005  0.019760  0.008838 -0.001919 -0.056906 -0.090491 -0.012819   \n",
       "files\\S_00006 -0.001017 -0.044305 -0.001919  0.049368  0.100709  0.164906   \n",
       "files\\S_00007 -0.011203 -0.031146 -0.001919 -0.032295 -0.041667 -0.012833   \n",
       "files\\S_00008 -0.009079 -0.085772 -0.001919 -0.027089 -0.096320 -0.012602   \n",
       "files\\S_00009  0.000589  0.119032 -0.001919 -0.029701 -0.081953 -0.012835   \n",
       "files\\S_00010 -0.017923 -0.084096 -0.001919  0.061069 -0.021878 -0.012700   \n",
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       "files\\S_00012  0.004161  0.140768 -0.001919  0.046860  0.014373  0.104097   \n",
       "files\\S_00013 -0.011302 -0.020541 -0.001919 -0.032367 -0.068388 -0.012817   \n",
       "files\\S_00014  0.055238  0.037187 -0.001919 -0.035348 -0.074731 -0.012834   \n",
       "files\\S_00015 -0.013839 -0.022348 -0.001919  0.035767  0.160057 -0.010429   \n",
       "files\\S_00016 -0.005847 -0.069068 -0.001919 -0.032269 -0.031985 -0.011481   \n",
       "files\\S_00017 -0.009916 -0.024780 -0.001919  0.052235  0.028051 -0.011453   \n",
       "files\\S_00018  0.040041  0.118045 -0.001919 -0.041849 -0.062433 -0.012531   \n",
       "files\\S_00019 -0.014184 -0.021491 -0.001919  0.003665  0.075382 -0.012746   \n",
       "files\\S_00020 -0.014222 -0.048061 -0.001919 -0.027353 -0.089776 -0.012842   \n",
       "files\\S_00021 -0.021807 -0.131936 -0.001919  0.102563  0.178199 -0.012364   \n",
       "files\\S_00022 -0.010517 -0.018936 -0.001919 -0.039199 -0.018764 -0.010409   \n",
       "files\\S_00023 -0.010778 -0.015872 -0.001919 -0.043740 -0.026900 -0.012828   \n",
       "files\\S_00024 -0.017919 -0.049355 -0.001919  0.067304  0.250108 -0.007520   \n",
       "files\\S_00025  0.028465  0.195686 -0.001919 -0.048679 -0.086321 -0.012680   \n",
       "files\\S_00026 -0.020601 -0.092913 -0.001919 -0.018687  0.268668 -0.012756   \n",
       "files\\S_00027 -0.006861  0.009831 -0.001919 -0.036240 -0.023974 -0.012528   \n",
       "files\\S_00028  0.000155 -0.009375 -0.001919 -0.003497 -0.018599 -0.012584   \n",
       "files\\S_00029 -0.010824 -0.040872 -0.001919  0.073392  0.090674 -0.012705   \n",
       "...                 ...       ...       ...       ...       ...       ...   \n",
       "files\\S_01188 -0.011225 -0.015729 -0.001919 -0.025830  0.771839 -0.012859   \n",
       "files\\S_01189  0.001367 -0.015809 -0.001919  0.002323 -0.024758 -0.012604   \n",
       "files\\S_01190 -0.019585 -0.097398  0.000923 -0.035061 -0.099453 -0.009994   \n",
       "files\\S_01191 -0.010984  0.001747 -0.001919  0.041236  0.043068 -0.010130   \n",
       "files\\S_01192 -0.015573  0.001679 -0.001919 -0.031223 -0.068444 -0.012859   \n",
       "files\\S_01193  0.002165  0.095144 -0.001919  0.000344  0.007211 -0.012859   \n",
       "files\\S_01194  0.005517 -0.018492 -0.001919 -0.013622 -0.075832 -0.012859   \n",
       "files\\S_01195 -0.014640 -0.052294 -0.001919 -0.042024 -0.093275 -0.012778   \n",
       "files\\S_01196  0.035382  0.229769  0.002261 -0.008990 -0.098776 -0.012859   \n",
       "files\\S_01197 -0.007378  0.006831 -0.001919 -0.038593 -0.081391 -0.012847   \n",
       "files\\S_01198 -0.011828 -0.014074 -0.001919 -0.047044 -0.121322 -0.012842   \n",
       "files\\S_01199 -0.006279  0.038078 -0.001919  0.011767 -0.068488 -0.012779   \n",
       "files\\S_01200 -0.008211 -0.075840 -0.001919 -0.044876 -0.103853 -0.012859   \n",
       "files\\S_01201 -0.019751 -0.123714 -0.001919 -0.000788 -0.046017  0.006600   \n",
       "files\\S_01202 -0.006567  0.050558 -0.001919 -0.002873 -0.077824  0.140734   \n",
       "files\\S_01203 -0.013292  0.004544 -0.001919 -0.033613 -0.050068 -0.012770   \n",
       "files\\S_01204 -0.009795  0.106694  0.000113 -0.032875 -0.065979 -0.012808   \n",
       "files\\S_01205  0.001447 -0.028282 -0.001919 -0.039662 -0.015855 -0.012818   \n",
       "files\\S_01206 -0.004751  0.089822 -0.001919 -0.057893 -0.053261 -0.012835   \n",
       "files\\S_01207  0.048436  0.038045 -0.001919 -0.049380 -0.041406  0.008767   \n",
       "files\\S_01208 -0.003731 -0.057122 -0.001919  0.021597 -0.074440 -0.012707   \n",
       "files\\S_01209 -0.016221 -0.125623 -0.001919 -0.032132 -0.051149 -0.010806   \n",
       "files\\S_01210  0.000405 -0.012054 -0.001919 -0.034861 -0.112690 -0.008506   \n",
       "files\\S_01211 -0.013558 -0.009083 -0.001919 -0.047660 -0.082996 -0.012829   \n",
       "files\\S_01212 -0.020007 -0.055764 -0.001919  0.148141  0.120764 -0.012606   \n",
       "files\\S_01213  0.002234  0.037585 -0.001919 -0.004476 -0.022732 -0.012791   \n",
       "files\\S_01214 -0.020285 -0.098864  0.000550 -0.018275  0.035250  0.009945   \n",
       "files\\S_01215 -0.009351 -0.023523  0.000538 -0.012475  0.150151 -0.012828   \n",
       "files\\S_01216  0.010551  0.081081 -0.001919  0.035450  0.002959 -0.012347   \n",
       "files\\S_01217  0.016355  0.163887 -0.001919 -0.043176 -0.026190 -0.012411   \n",
       "\n",
       "gene_symbol      A4GALT     A4GNT      AAAS      AACS    ...       ZWILCH  \\\n",
       "sample                                                   ...                \n",
       "files\\S_00000 -0.061381 -0.045606  0.068908 -0.024065    ...    -0.083996   \n",
       "files\\S_00001 -0.042468  0.038707 -0.022627 -0.017736    ...     0.037113   \n",
       "files\\S_00002  0.105948 -0.045606 -0.027905 -0.014165    ...    -0.086921   \n",
       "files\\S_00003 -0.036427 -0.045606  0.126306 -0.021871    ...     0.050218   \n",
       "files\\S_00004 -0.021000  0.188451 -0.027289  0.011058    ...     0.209429   \n",
       "files\\S_00005  0.037716 -0.024891  0.301678  0.020959    ...    -0.037814   \n",
       "files\\S_00006  0.412728  0.003319 -0.090785 -0.001687    ...     0.034374   \n",
       "files\\S_00007 -0.026176  0.008249 -0.162653 -0.022629    ...     0.032308   \n",
       "files\\S_00008 -0.029374 -0.045606 -0.048068 -0.008175    ...     0.002860   \n",
       "files\\S_00009 -0.016899 -0.045606 -0.016826 -0.006958    ...     0.051046   \n",
       "files\\S_00010 -0.005959  0.000962 -0.001249  0.055962    ...     0.006336   \n",
       "files\\S_00011 -0.037963  0.091073  0.178853 -0.033243    ...    -0.006874   \n",
       "files\\S_00012  0.203209  0.025176 -0.268831 -0.029895    ...     0.074763   \n",
       "files\\S_00013 -0.063140 -0.045606 -0.129732 -0.037178    ...    -0.045541   \n",
       "files\\S_00014 -0.043533 -0.045606 -0.017734  0.013769    ...    -0.084606   \n",
       "files\\S_00015  0.035751  0.007241 -0.109392 -0.017470    ...    -0.057708   \n",
       "files\\S_00016 -0.002745 -0.016254 -0.092478 -0.032725    ...    -0.010505   \n",
       "files\\S_00017 -0.023584  0.010399 -0.122775 -0.021720    ...    -0.014317   \n",
       "files\\S_00018 -0.049444 -0.045606  0.257001 -0.006687    ...     0.074536   \n",
       "files\\S_00019  0.004795 -0.045606 -0.043945 -0.013854    ...    -0.024860   \n",
       "files\\S_00020 -0.033658  0.060631 -0.065172 -0.005848    ...     0.056793   \n",
       "files\\S_00021  0.068021  0.114243 -0.096225  0.005001    ...    -0.077884   \n",
       "files\\S_00022 -0.027038 -0.014693  0.025902  0.014114    ...    -0.033522   \n",
       "files\\S_00023 -0.014437 -0.045606 -0.199590  0.010535    ...    -0.007234   \n",
       "files\\S_00024 -0.038154  0.005277 -0.147033 -0.009194    ...     0.000214   \n",
       "files\\S_00025 -0.060690  0.137258  0.027828  0.031303    ...     0.150369   \n",
       "files\\S_00026 -0.072018 -0.033873  0.069490 -0.017025    ...     0.261894   \n",
       "files\\S_00027 -0.038714 -0.016197  0.130037  0.058079    ...    -0.000446   \n",
       "files\\S_00028 -0.041161  0.021361 -0.042456 -0.014759    ...    -0.022323   \n",
       "files\\S_00029  0.026853 -0.045606 -0.017011  0.028424    ...    -0.039492   \n",
       "...                 ...       ...       ...       ...    ...          ...   \n",
       "files\\S_01188 -0.078703 -0.012285  0.006282 -0.003074    ...    -0.048281   \n",
       "files\\S_01189 -0.018979  0.171488 -0.056117 -0.019066    ...    -0.008134   \n",
       "files\\S_01190 -0.056422 -0.045606 -0.261748 -0.007072    ...    -0.012401   \n",
       "files\\S_01191 -0.026853 -0.023816 -0.011181 -0.008089    ...    -0.084989   \n",
       "files\\S_01192 -0.076756 -0.030028 -0.079565  0.035476    ...     0.072887   \n",
       "files\\S_01193 -0.025091 -0.045606  0.105222 -0.000018    ...    -0.034868   \n",
       "files\\S_01194 -0.063005 -0.045606  0.122289  0.005714    ...     0.253377   \n",
       "files\\S_01195 -0.063927 -0.024906  0.077654 -0.010038    ...     0.208209   \n",
       "files\\S_01196  0.020030 -0.045606  0.146259 -0.033274    ...    -0.048323   \n",
       "files\\S_01197 -0.052398 -0.008114 -0.044427 -0.003482    ...     0.010064   \n",
       "files\\S_01198 -0.070188 -0.045606 -0.060533 -0.026410    ...    -0.038451   \n",
       "files\\S_01199 -0.015966 -0.018151 -0.128525  0.024990    ...    -0.033362   \n",
       "files\\S_01200 -0.057588  0.003866  0.064976 -0.022843    ...     0.045491   \n",
       "files\\S_01201 -0.033275 -0.045606 -0.195090 -0.016860    ...    -0.054067   \n",
       "files\\S_01202 -0.051229 -0.045606 -0.221330 -0.029894    ...     0.112257   \n",
       "files\\S_01203 -0.042963 -0.027428  0.036005 -0.025358    ...     0.094535   \n",
       "files\\S_01204  0.029045 -0.045606  0.007560  0.042541    ...    -0.071533   \n",
       "files\\S_01205  0.099168 -0.045606  0.000675  0.054908    ...    -0.038731   \n",
       "files\\S_01206 -0.073305 -0.033191  0.107057  0.050549    ...    -0.054053   \n",
       "files\\S_01207  0.028869 -0.045606  0.220688 -0.006788    ...    -0.065671   \n",
       "files\\S_01208 -0.055602 -0.045606  0.020310 -0.008127    ...     0.283114   \n",
       "files\\S_01209 -0.064229 -0.045606 -0.097033  0.092394    ...     0.191560   \n",
       "files\\S_01210 -0.030728 -0.045606  0.111276  0.006289    ...     0.105207   \n",
       "files\\S_01211  0.037952 -0.014823 -0.176027 -0.032312    ...     0.006682   \n",
       "files\\S_01212  0.085965  0.030623 -0.126850  0.007113    ...    -0.080282   \n",
       "files\\S_01213  0.070687 -0.045606 -0.123137 -0.031214    ...     0.023694   \n",
       "files\\S_01214 -0.057349 -0.029806 -0.191020 -0.032692    ...     0.031299   \n",
       "files\\S_01215 -0.071377 -0.029878 -0.102747 -0.034577    ...     0.002420   \n",
       "files\\S_01216  0.021209 -0.027552 -0.033822  0.011088    ...     0.013426   \n",
       "files\\S_01217  0.045739 -0.045606  0.060144  0.009428    ...    -0.055846   \n",
       "\n",
       "gene_symbol       ZWINT      ZXDA      ZXDB      ZXDC    ZYG11A    ZYG11B  \\\n",
       "sample                                                                      \n",
       "files\\S_00000 -0.066670 -0.011267  0.162704 -0.055114 -0.100084 -0.016662   \n",
       "files\\S_00001 -0.016512  0.436350  0.096898  0.045728 -0.034231 -0.007081   \n",
       "files\\S_00002 -0.032436 -0.290789 -0.131170 -0.315873 -0.068697 -0.038764   \n",
       "files\\S_00003 -0.010358 -0.123919 -0.070297 -0.070831 -0.042049 -0.044519   \n",
       "files\\S_00004 -0.071915  0.201767  0.068041  0.357255 -0.046245  0.008294   \n",
       "files\\S_00005  0.081407 -0.258590 -0.119091 -0.184770  0.031541 -0.032016   \n",
       "files\\S_00006 -0.012908 -0.140607 -0.105064 -0.296882 -0.049306 -0.033781   \n",
       "files\\S_00007  0.164518 -0.017272  0.002394  0.091883  0.106779  0.009702   \n",
       "files\\S_00008  0.101571 -0.072159 -0.017036 -0.195083 -0.054054 -0.028544   \n",
       "files\\S_00009 -0.027825  0.140211  0.214329 -0.028200  0.076847 -0.002491   \n",
       "files\\S_00010 -0.067611  0.157516 -0.019220  0.150409 -0.095591  0.035093   \n",
       "files\\S_00011 -0.009413  0.006680 -0.017644  0.085293 -0.048306 -0.026235   \n",
       "files\\S_00012  0.038820  0.049879 -0.040534 -0.167621 -0.097712 -0.005182   \n",
       "files\\S_00013 -0.063832  0.089562  0.014667 -0.037710  0.001776  0.022886   \n",
       "files\\S_00014 -0.054286 -0.253857 -0.067048 -0.104436 -0.063216 -0.049833   \n",
       "files\\S_00015 -0.091505 -0.018177 -0.027213 -0.021741 -0.094393  0.014542   \n",
       "files\\S_00016 -0.026387 -0.050771 -0.014457  0.077229 -0.067288 -0.024433   \n",
       "files\\S_00017 -0.065560  0.158196 -0.005736  0.139891 -0.060949  0.014507   \n",
       "files\\S_00018  0.052744  0.056861 -0.012619  0.033759  0.266655 -0.008512   \n",
       "files\\S_00019 -0.043012  0.106794  0.615428 -0.067357 -0.102914 -0.033333   \n",
       "files\\S_00020  0.125606  0.051984  0.034541  0.023553  0.081468  0.026432   \n",
       "files\\S_00021 -0.091176  0.048613 -0.063574 -0.047146 -0.116528  0.042428   \n",
       "files\\S_00022  0.017408  0.331971  0.099001  0.051068  0.249478 -0.000643   \n",
       "files\\S_00023  0.025840  0.154324  0.122427  0.220397  0.116623  0.011674   \n",
       "files\\S_00024 -0.070495  0.188229  0.037915  0.037621  0.003692  0.052179   \n",
       "files\\S_00025  0.288079  0.095812  0.206392 -0.098504  0.206350 -0.005566   \n",
       "files\\S_00026  0.001268  0.346448  0.209832  0.197594 -0.038464  0.025752   \n",
       "files\\S_00027 -0.024873  0.074182  0.014113  0.058549  0.097390  0.008207   \n",
       "files\\S_00028 -0.068852  0.120748 -0.001400  0.009910 -0.002007 -0.006026   \n",
       "files\\S_00029 -0.017842  0.125973  0.146174 -0.026435  0.021112  0.022886   \n",
       "...                 ...       ...       ...       ...       ...       ...   \n",
       "files\\S_01188 -0.031260  0.373797  0.170216  0.476591 -0.086674  0.036805   \n",
       "files\\S_01189 -0.067834 -0.088268 -0.080148 -0.063745 -0.010297 -0.032699   \n",
       "files\\S_01190  0.053542  0.082127  0.080000  0.069400  0.553334  0.088010   \n",
       "files\\S_01191 -0.090060  0.128841 -0.026492  0.061371 -0.086204  0.001111   \n",
       "files\\S_01192  0.052892  0.082044  0.039180 -0.027177 -0.072596  0.012741   \n",
       "files\\S_01193 -0.032995 -0.154993 -0.024512 -0.189114  0.050297 -0.019171   \n",
       "files\\S_01194  0.150619 -0.026525  0.095031 -0.087541 -0.074291 -0.008396   \n",
       "files\\S_01195  0.137211  0.006032  0.032401  0.051115  0.121024 -0.023093   \n",
       "files\\S_01196 -0.030992 -0.036270  0.044934  0.001455 -0.101582 -0.021710   \n",
       "files\\S_01197  0.024436 -0.082327  0.284444  0.243908 -0.105018  0.001086   \n",
       "files\\S_01198 -0.075712 -0.009415  0.007050  0.335551 -0.027234  0.029998   \n",
       "files\\S_01199 -0.046953 -0.083642 -0.069443  0.002266 -0.114151 -0.011426   \n",
       "files\\S_01200  0.144959  0.479003  0.433401 -0.054242  0.094397  0.004228   \n",
       "files\\S_01201  0.049986 -0.156341 -0.104375 -0.205407  0.031289 -0.011614   \n",
       "files\\S_01202  0.026764 -0.075313 -0.039333  0.045272  0.111149  0.007031   \n",
       "files\\S_01203  0.218085  0.389425  0.175188  0.107639  0.060214 -0.006601   \n",
       "files\\S_01204  0.034191 -0.056137  0.029792  0.006060 -0.052845  0.007228   \n",
       "files\\S_01205 -0.039589 -0.042970 -0.028912 -0.093450 -0.110796 -0.008760   \n",
       "files\\S_01206 -0.003505  0.029892  0.000295  0.048513 -0.094962  0.012964   \n",
       "files\\S_01207 -0.001212 -0.300977 -0.152590  0.102348 -0.006638 -0.038584   \n",
       "files\\S_01208 -0.048257 -0.065248 -0.019718 -0.021592 -0.094635 -0.002573   \n",
       "files\\S_01209  0.210122 -0.093988 -0.012365 -0.265940  0.029237 -0.020841   \n",
       "files\\S_01210  0.111661  0.087417  0.026984  0.197243  0.005054 -0.016863   \n",
       "files\\S_01211 -0.032000 -0.151347  0.050594 -0.188265  0.047900  0.022157   \n",
       "files\\S_01212 -0.097641  0.090200 -0.037654  0.004617 -0.097448  0.032358   \n",
       "files\\S_01213 -0.064942  0.074122  0.006973 -0.060151 -0.075884 -0.009719   \n",
       "files\\S_01214 -0.005428 -0.025373  0.048960 -0.159824  0.091666  0.041617   \n",
       "files\\S_01215 -0.072974  0.109418  0.027419  0.077121 -0.041065  0.052579   \n",
       "files\\S_01216 -0.027136 -0.194378 -0.040735 -0.114754 -0.105077 -0.027561   \n",
       "files\\S_01217 -0.050234 -0.033420  0.006828  0.000488 -0.086686 -0.001129   \n",
       "\n",
       "gene_symbol         ZYX     ZZEF1      ZZZ3  \n",
       "sample                                       \n",
       "files\\S_00000 -0.116856  0.052615 -0.017679  \n",
       "files\\S_00001 -0.008640  0.091150 -0.033336  \n",
       "files\\S_00002  0.014137 -0.077970 -0.068468  \n",
       "files\\S_00003  0.094634 -0.035120 -0.067507  \n",
       "files\\S_00004  0.019050 -0.020601 -0.010376  \n",
       "files\\S_00005 -0.080422 -0.152367 -0.071242  \n",
       "files\\S_00006  0.115934 -0.107207 -0.049489  \n",
       "files\\S_00007 -0.076293  0.050516  0.026719  \n",
       "files\\S_00008  0.013020 -0.144900 -0.064708  \n",
       "files\\S_00009  0.095539  0.045081  0.009274  \n",
       "files\\S_00010  0.093114  0.103718  0.056304  \n",
       "files\\S_00011 -0.042929  0.011082  0.001280  \n",
       "files\\S_00012  0.140560 -0.029778  0.008777  \n",
       "files\\S_00013 -0.080726  0.106555  0.071340  \n",
       "files\\S_00014  0.061167 -0.126223 -0.090815  \n",
       "files\\S_00015  0.182137  0.007753  0.004360  \n",
       "files\\S_00016 -0.034495 -0.053974 -0.048735  \n",
       "files\\S_00017  0.013352  0.116413  0.020872  \n",
       "files\\S_00018 -0.055186 -0.006825  0.013554  \n",
       "files\\S_00019 -0.050017 -0.080577 -0.041050  \n",
       "files\\S_00020 -0.080726  0.020699  0.004248  \n",
       "files\\S_00021  0.007117  0.077565 -0.039884  \n",
       "files\\S_00022 -0.065780 -0.021172  0.038240  \n",
       "files\\S_00023 -0.111781 -0.075605  0.020012  \n",
       "files\\S_00024 -0.021201  0.085970  0.055222  \n",
       "files\\S_00025 -0.046907 -0.071873 -0.023772  \n",
       "files\\S_00026 -0.104435  0.185058 -0.013550  \n",
       "files\\S_00027 -0.083204  0.023358 -0.010152  \n",
       "files\\S_00028  0.026455  0.057706  0.007946  \n",
       "files\\S_00029 -0.063498 -0.059252 -0.027090  \n",
       "...                 ...       ...       ...  \n",
       "files\\S_01188 -0.125978  0.185997  0.036492  \n",
       "files\\S_01189  0.240625 -0.003883 -0.040242  \n",
       "files\\S_01190 -0.134162 -0.058226  0.017770  \n",
       "files\\S_01191  0.180681 -0.001011  0.030157  \n",
       "files\\S_01192 -0.105019  0.093938 -0.016177  \n",
       "files\\S_01193 -0.019669 -0.110278 -0.017877  \n",
       "files\\S_01194  0.074981 -0.028715 -0.044110  \n",
       "files\\S_01195 -0.059456 -0.060536 -0.032726  \n",
       "files\\S_01196  0.017028  0.000647 -0.003931  \n",
       "files\\S_01197 -0.051842 -0.033155  0.017053  \n",
       "files\\S_01198 -0.062210  0.079449  0.021733  \n",
       "files\\S_01199  0.095546 -0.015629 -0.055528  \n",
       "files\\S_01200 -0.091820  0.009292  0.060006  \n",
       "files\\S_01201  0.184994 -0.077608 -0.018565  \n",
       "files\\S_01202  0.031026 -0.078165 -0.032025  \n",
       "files\\S_01203 -0.058442 -0.164488 -0.057725  \n",
       "files\\S_01204 -0.041702 -0.032029  0.005686  \n",
       "files\\S_01205 -0.012030  0.006025 -0.027728  \n",
       "files\\S_01206 -0.128101  0.219724  0.105166  \n",
       "files\\S_01207  0.036630 -0.114917 -0.055788  \n",
       "files\\S_01208 -0.029764 -0.118543  0.012562  \n",
       "files\\S_01209 -0.069171 -0.017707 -0.020014  \n",
       "files\\S_01210 -0.082793  0.050263 -0.014560  \n",
       "files\\S_01211  0.016504 -0.161963 -0.038962  \n",
       "files\\S_01212  0.041883  0.088447  0.001792  \n",
       "files\\S_01213  0.012161 -0.046251 -0.008874  \n",
       "files\\S_01214 -0.062605 -0.094318  0.110151  \n",
       "files\\S_01215 -0.059383 -0.073076  0.133646  \n",
       "files\\S_01216 -0.014157 -0.053278 -0.025395  \n",
       "files\\S_01217 -0.074410 -0.014959 -0.042733  \n",
       "\n",
       "[1218 rows x 20207 columns]"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "regiondata = (regiondata - regiondata.mean())\n",
    "regiondata = regiondata / (regiondata.max() - regiondata.min())\n",
    "regiondata\n"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Save base data to pickel file"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "pickle_file = \"./gmql_data/Datasets/breast_data_all_w_labels.p\"\n",
    "\n",
    "try:\n",
    "    \n",
    "    f = open(pickle_file, 'wb')\n",
    "    save = {\n",
    "    'data': regiondata,\n",
    "    'labels': lbls,\n",
    "\n",
    "    }\n",
    "    pickle.dump(save, f, pickle.HIGHEST_PROTOCOL)\n",
    "    f.close()\n",
    "except Exception as e:\n",
    "    print('Unable to save data to', pickle_file, ':', e)\n",
    "    raise\n",
    "\n",
    "    \n",
    "    \n",
    "    "
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# Split the data for train and test"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "from sklearn.model_selection import StratifiedKFold\n",
    "from sklearn.model_selection import StratifiedShuffleSplit\n",
    "import pickle\n",
    "import numpy as np"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {
    "collapsed": true,
    "scrolled": true
   },
   "outputs": [],
   "source": [
    "pickle_file = \"./gmql_data/Datasets/breast_data_all_w_labels.p\"\n",
    "with open(pickle_file, 'rb') as f:\n",
    "    save = pickle.load(f)\n",
    "    data = save['data']\n",
    "    labels = save['labels']\n",
    "    del save  # hint to help gc free up memory"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Set labels to y parameter"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "StratifiedShuffleSplit(n_splits=5, random_state=0, test_size=0.2,\n",
       "            train_size=None)"
      ]
     },
     "execution_count": 13,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "x = np.array(data)\n",
    "y = np.array(labels)\n",
    "sss = StratifiedShuffleSplit(n_splits=5, test_size=0.2, random_state=0)\n",
    "sss.get_n_splits(x, y)\n",
    "sss"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "for train_index, test_index in sss.split(x, y):\n",
    "    x_train, x_test = x[train_index], x[test_index]\n",
    "    y_train, y_test = y[train_index], y[test_index]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "array([[  3.64955840e-02,   6.56495584e-02,  -1.91896358e-03, ...,\n",
       "          2.96413139e-01,  -7.91427000e-02,  -6.74707876e-02],\n",
       "       [ -1.13294452e-02,  -5.00542809e-02,   6.57146755e-04, ...,\n",
       "          8.42893195e-02,  -2.82782310e-02,  -3.22926989e-03],\n",
       "       [  4.54403260e-03,  -4.36160967e-02,  -1.91896358e-03, ...,\n",
       "         -5.31132268e-03,  -3.00328050e-02,  -2.88051799e-02],\n",
       "       ..., \n",
       "       [  1.48092168e-03,  -2.25529199e-02,  -1.91896358e-03, ...,\n",
       "          1.65910790e-01,  -1.12622739e-01,  -5.25454215e-02],\n",
       "       [  1.59026182e-02,  -2.78852836e-02,  -1.91896358e-03, ...,\n",
       "         -2.48721912e-02,   3.29267534e-02,  -5.37449511e-02],\n",
       "       [ -9.01547059e-03,   5.23519195e-02,   1.58883409e-04, ...,\n",
       "         -8.20295370e-02,   2.87572403e-02,   2.17958499e-02]])"
      ]
     },
     "execution_count": 15,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "x_train"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "array([[ 0.00952662,  0.07903196, -0.00191896, ...,  0.0244242 ,\n",
       "         0.00273361,  0.02826876],\n",
       "       [-0.0086106 , -0.00866633, -0.00191896, ...,  0.3565846 ,\n",
       "        -0.04618902, -0.02720396],\n",
       "       [-0.02021831, -0.05124313, -0.00191896, ..., -0.03760679,\n",
       "        -0.01531181,  0.00319299],\n",
       "       ..., \n",
       "       [-0.00858663,  0.01394642, -0.00191896, ..., -0.10437944,\n",
       "         0.11332992, -0.01063095],\n",
       "       [-0.00575942,  0.04758959,  0.00246931, ..., -0.02601109,\n",
       "        -0.00456936,  0.03479808],\n",
       "       [ 0.00245662,  0.02299445, -0.00191896, ...,  0.1117065 ,\n",
       "        -0.10361324, -0.02543221]])"
      ]
     },
     "execution_count": 16,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "x_test"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "array([1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1,\n",
       "       1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 0, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 0, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 1, 1, 1, 0, 1, 1, 0,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 0, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 0, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 0, 1, 1, 1, 1, 1, 1, 0, 0, 1, 0, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1,\n",
       "       1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 0, 1, 1, 1, 1, 1, 0,\n",
       "       0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 0, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1,\n",
       "       0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1,\n",
       "       0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 0, 1, 1, 1, 1, 0, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 0, 1, 1, 0, 1, 1, 1,\n",
       "       1, 0, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1,\n",
       "       0, 1, 0, 1, 1, 0, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 0, 0, 0, 0, 1, 1, 1, 1, 1,\n",
       "       1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1,\n",
       "       1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 0, 1, 1, 1, 1,\n",
       "       1, 1, 1, 0, 1, 1, 1, 1])"
      ]
     },
     "execution_count": 17,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "y_train"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "array([1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 0, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 0, 1, 1, 1, 0, 1, 1, 1, 1, 1, 0, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 0, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1,\n",
       "       1, 0, 0, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 0, 1, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 0, 0, 1, 1, 0, 1, 1, 1, 1, 1, 1, 1, 1, 0, 0, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1,\n",
       "       1, 1, 1, 1, 1, 1, 1, 1, 0, 1, 1, 1, 1, 1])"
      ]
     },
     "execution_count": 18,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "y_test"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Check if the input raito is preserved. Check wit y data since its easier to see"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Create validation dataset from training data"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "StratifiedShuffleSplit(n_splits=3, random_state=0, test_size=0.25,\n",
       "            train_size=None)"
      ]
     },
     "execution_count": 19,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "x = x_train\n",
    "z = y_train\n",
    "\n",
    "sss = StratifiedShuffleSplit(n_splits=3, test_size=0.25, random_state=0)\n",
    "sss.get_n_splits(x, z)\n",
    "sss"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "for train_index, valid_index in sss.split(x, z):\n",
    "    x_train, x_valid = x[train_index], x[valid_index]\n",
    "    z_train, z_valid = z[train_index], z[valid_index]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "array([[ -5.87087715e-03,   1.67402084e-02,  -1.91896358e-03, ...,\n",
       "         -3.89933588e-02,  -9.17438951e-02,   2.70760013e-01],\n",
       "       [ -1.60209429e-02,  -4.60008358e-02,  -1.91896358e-03, ...,\n",
       "         -1.59804769e-02,   4.05359671e-02,   3.77925855e-02],\n",
       "       [ -2.00440391e-02,  -7.11853823e-02,  -1.91896358e-03, ...,\n",
       "          1.62880760e-02,   8.86200330e-02,   4.92304606e-02],\n",
       "       ..., \n",
       "       [ -1.45239724e-02,   1.47595591e-04,  -1.91896358e-03, ...,\n",
       "          9.79498384e-03,   6.98798585e-02,   5.61715019e-03],\n",
       "       [ -1.65479750e-02,  -8.87773736e-02,  -1.91896358e-03, ...,\n",
       "          1.42898974e-01,   1.74705162e-02,  -4.45273991e-02],\n",
       "       [ -1.70140369e-02,  -5.24773068e-02,  -1.91896358e-03, ...,\n",
       "          3.88878964e-02,   1.79739371e-02,   3.88155975e-02]])"
      ]
     },
     "execution_count": 21,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "x_valid"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Save the data for future use"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "pickle_file = \"./gmql_data/Datasets/breast_data_all_divided_4.pickle\"\n",
    "\n",
    "try:\n",
    "  f = open(pickle_file, 'wb')\n",
    "  save = {\n",
    "    'train_dataset': x_train,\n",
    "    'train_labels': z_train,\n",
    "    'test_dataset': x_test,\n",
    "    'test_labels': y_test,\n",
    "    'valid_dataset': x_valid,\n",
    "    'valid_labels': z_valid,\n",
    "    }\n",
    "  pickle.dump(save, f, pickle.HIGHEST_PROTOCOL)\n",
    "  f.close()\n",
    "except Exception as e:\n",
    "  print('Unable to save data to', pickle_file, ':', e)\n",
    "  raise"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": []
  }
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