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MAGIC and batches #199

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AVitriolo opened this issue Feb 4, 2022 · 1 comment
Open

MAGIC and batches #199

AVitriolo opened this issue Feb 4, 2022 · 1 comment

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@AVitriolo
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Ciao,

I am currently using MAGIC before integration/batch correction but -for many reasons - I am now considering modifying a bit your work, to inform MAGIC with an alternative PCA or set of distances, specifically generated after batch(etc)-correction. I'm not considering modifying count values in the input at the moment.
Since it's not described explicitly here, and I have not even started to seriously delve into the code, I was wondering if this possibility is already there as an easter-egg, or if you are already working on this.

@LiuCanidk
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Hi there, I have the same idea on the batch integration and wonder if I can input the embedding of batch effect removal, e.g., harmony embedding, to the magic function, is there any progress? or should I perform magic over each individual sample and then merge them?
Thanks in advance

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